Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production.

Lipopolysaccharide (LPS), a product of Gram-negative bacteria, is potent mediator of tumor necrosis factor (TNF)alpha production by myeloid/macrophage cells. Inhibitors capable of blocking the signaling events that result in TNF alpha production could provide useful therapeutics for treating septic...

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Bibliografische gegevens
Hoofdauteurs: Horwood, N, Mahon, T, McDaid, J, Campbell, J, Mano, H, Brennan, F, Webster, D, Foxwell, B
Formaat: Journal article
Taal:English
Gepubliceerd in: 2003