Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis

Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis

The aim of this study was to investigate the pathogenesis of combination ipilimumab and nivolumab-associated colitis (IN-COL) by measuring gut-derived and peripheral blood mononuclear cell (GMNC; PBMC) profiles. We studied GMNC and PBMC from patients with IN-COL, IN-treated with no adverse-events (I...

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Главные авторы: Sasson, SC, Zaunders, JJ, Nahar, K, Munier, CML, Fairfax, BP, Olsson-Brown, A, Jolly, C, Read, SA, Ahlenstiel, G, Palendira, U, Scolyer, RA, Carlino, MS, Payne, MJ, Cheung, VTF, Gupta, T, Klenerman, P, Long, GV, Brain, O, Menzies, AM, Kelleher, AD
Формат: Journal article
Язык:English
Опубликовано: Wiley 2020

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