Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

BACKGROUND: Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS: We have generated extensive physiological, genetic and genome-wide gene expression profiles in a congen...

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Bibliografiske detaljer
Main Authors:	Wallis, R, Collins, S, Kaisaki, P, Argoud, K, Wilder, S, Wallace, K, Ria, M, Ktorza, A, Rorsman, P, Bihoreau, M, Gauguier, D
Format:	Journal article
Sprog:	English
Udgivet:	Public Library of Science 2008

Lignende værker

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
af: Robert H Wallis, et al.
Udgivet: (2008-08-01)

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.
af: Collins, S, et al.
Udgivet: (2006)

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.
af: Wallace, K, et al.
Udgivet: (2004)

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.
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Udgivet: (2004)

Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats.
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Udgivet: (2006)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.
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Udgivet: (2009)

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
af: Kaisaki, P, et al.
Udgivet: (2016)

Construction of congenic lines for the locus Nidd/gk1 controlling glucose tolerance in the GK rat.
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Udgivet: (1999)

Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
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Udgivet: (2006)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.
af: Wilder, S, et al.
Udgivet: (2004)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
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Udgivet: (2004)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes
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Udgivet: (2009-02-01)

Report on rat chromosome 4
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Udgivet: (1999)

Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.
af: Collins, S, et al.
Udgivet: (2003)

QTL dissection using a GK.BN F2 cohort derived from a congenic line.
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Udgivet: (2003)

Genetic cartography of gene expression in white adipose tissue in the GK rat
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Udgivet: (2011)

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A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes.
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Udgivet: (1999)

Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint.
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Udgivet: (2000)

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Udgivet: (1990)

Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.
af: Gauguier, D, et al.
Udgivet: (2005)

A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.
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Udgivet: (2001)

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Udgivet: (1997)

Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus
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Udgivet: (2009)

Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models.
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Udgivet: (2007)

Genetic control of differential acetylation in diabetic rats
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Udgivet: (2014)

Genetic dissection of a diabetes QTL in congenic lines of the GK rat and synteny conservation with diabetes susceptibility loci in human 1q.
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Udgivet: (2003)

Medical Genetics: revenge of the thrift.
af: Kaisaki, P, et al.
Udgivet: (2005)

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.
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Udgivet: (2007)

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Udgivet: (1995)

Genome-wide sequencing and gene expression QTL mapping in the Goto-Kakizaki rat identify Ascl3 as a regulator of adipocyte function
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Udgivet: (2011)

Uncoupling proteins 2 and 3 (UCP2/3) map to a region linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) diabetic rat
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Udgivet: (1998)

Chromosomal mapping of quantitative trait loci controlling components of the aortic extracellular matrix in the Brown Norway rat
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Udgivet: (2004)

miRNA expression profile in rats correlates with type-2-diabetes phenotype
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Udgivet: (2008)

Multiple diabetes QTL on rat chromosome 1 defined by GK rat congenic lines
af: Collins, S, et al.
Udgivet: (2002)

Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
af: Gauguier, D, et al.
Udgivet: (1996)

Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat.
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Udgivet: (1998)

Pathophysiology of the cardio-renal syndromes types 1–5: An uptodate
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Udgivet: (2017-03-01)