Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose:glycoprotein glucosyltransferase

UDP-glucose:glycoprotein glucosyltransferase (UGGT) flags misfolded glycoproteins for ER retention. We report crystal structures of full-length Chaetomium thermophilum UGGT (CtUGGT), two CtUGGT double-cysteine mutants, and its TRXL2 domain truncation (CtUGGT-ΔTRXL2). CtUGGT molecular dynamics (MD) s...

Descripció completa

Dades bibliogràfiques
Autors principals:	Modenutti, CP, Blanco Capurro, JI, Ibba, R, Alonzi, DS, Song, MN, Vasiljević, S, Kumar, A, Chandran, AV, Tax, G, Marti, L, Hill, JC, Lia, A, Hensen, M, Waksman, T, Rushton, J, Rubichi, S, Santino, A, Martí, MA, Zitzmann, N, Roversi, P
Format:	Journal article
Idioma:	English
Publicat:	Cell Press 2020

Ítems similars

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP-glucose: glycoprotein glucosyl-transferase
per: Modenutti, CP, et al.
Publicat: (2020)

TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway
per: Andreas Neerincx, et al.
Publicat: (2017-04-01)

The UDP-glucosyltransferase multigene family in <it>Bombyx mori</it>
per: Lu Cheng, et al.
Publicat: (2008-11-01)

Role of UDP-glucose ceramide glucosyltransferase in venous malformation
per: Sheng Chen, et al.
Publicat: (2023-05-01)

Rescue of secretion of rare-disease associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells
per: Tax, G, et al.
Publicat: (2024)

Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity
per: Fei Guo, et al.
Publicat: (2022-10-01)

Identification and Functional Characterisation of Two Oat UDP-Glucosyltransferases Involved in Deoxynivalenol Detoxification
per: Alfia Khairullina, et al.
Publicat: (2022-06-01)

Inactivation of UDP-Glucose Sterol Glucosyltransferases Enhances Arabidopsis Resistance to Botrytis cinerea
per: Nidia Castillo, et al.
Publicat: (2019-09-01)

Validation of a Candidate Deoxynivalenol-Inactivating UDP-Glucosyltransferase from Barley by Heterologous Expression in Yeast
per: Wolfgang Schweiger, et al.
Publicat: (2010-07-01)

Characterization of a heat responsive UDP: Flavonoid glucosyltransferase gene in tea plant (Camellia sinensis).
per: Xiaojia Su, et al.
Publicat: (2018-01-01)

Characterization of UGT716A1 as a Multi-substrate UDP:Flavonoid Glucosyltransferase Gene in Ginkgo biloba
per: Xiaojia Su, et al.
Publicat: (2017-12-01)

Systematic analysis of the UDP-glucosyltransferase family: discovery of a member involved in rutin biosynthesis in Solanum melongena
per: Yuwei Gan, et al.
Publicat: (2023-12-01)

UDP-glucosyltransferase OsUGT75A promotes submergence tolerance during rice seed germination
per: Yongqi He, et al.
Publicat: (2023-04-01)

Alternative transcript splicing regulates UDP-glucosyltransferase-catalyzed detoxification of DIMBOA in the fall armyworm (Spodoptera frugiperda)
per: Bhawana Israni, et al.
Publicat: (2022-06-01)

UDP-glucosyltransferase regulates grain size and abiotic stress tolerance associated with metabolic flux redirection in rice
per: Nai-Qian Dong, et al.
Publicat: (2020-05-01)

Author Correction: Alternative transcript splicing regulates UDP-glucosyltransferase-catalyzed detoxification of DIMBOA in the fall armyworm (Spodoptera frugiperda)
per: Bhawana Israni, et al.
Publicat: (2022-08-01)

Transgenic Wheat Expressing a Barley UDP-Glucosyltransferase Detoxifies Deoxynivalenol and Provides High Levels of Resistance to Fusarium graminearum
per: Xin Li, et al.
Publicat: (2015-11-01)

Identification and Characterization of DcUSAGT1, a UDP-Glucose: Sinapic Acid Glucosyltransferase from Purple Carrot Taproots.
per: Yi-Yun Chen, et al.
Publicat: (2016-01-01)

Ecdysteroid UDP-Glucosyltransferase Expression in <i>Beauveria bassiana</i> Increases Its Pathogenicity against Early Instar Silkworm Larvae
per: Xueqin Mao, et al.
Publicat: (2023-10-01)

Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-β-D-glucoside
per: Herbert Michlmayr, et al.
Publicat: (2015-07-01)

In planta preliminary screening of ER glycoprotein folding quality control (ERQC) modulators
per: Marti, L, et al.
Publicat: (2018)

Auxin-Glucose Conjugation Protects the Rice (Oryza sativa L.) Seedlings Against Hydroxyurea-Induced Phytotoxicity by Activating UDP-Glucosyltransferase Enzyme
per: Vimalraj Kantharaj, et al.
Publicat: (2022-02-01)

A Ubiquitously Expressed UDP-Glucosyltransferase, <i>UGT74J1</i>, Controls Basal Salicylic Acid Levels in Rice
per: Daisuke Tezuka, et al.
Publicat: (2021-09-01)

UDP-Glucosyltransferases from Rice, Brachypodium, and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-d-glucosides
per: Herbert Michlmayr, et al.
Publicat: (2018-03-01)

Study of ceramide glucosyltransferase
per: Narita, K, et al.
Publicat: (2001)

Analysis of the UDP-Glucosyltransferase (<i>UGT</i>) Gene Family and Its Functional Involvement in Drought and Salt Stress Tolerance in <i>Phoebe bournei</i>
per: Hengfeng Guan, et al.
Publicat: (2024-03-01)

Making the most of crystal polymorphism in fragment-based lead discovery
per: Caputo, AT, et al.
Publicat: (2023)

Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint
per: Caputo, AT, et al.
Publicat: (2022)

The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design
per: Carlos P. Modenutti, et al.
Publicat: (2019-12-01)

Bioconversion of Corticosterone into Corticosterone-Glucoside by Glucosyltransferase
per: Tokutaro Yamaguchi, et al.
Publicat: (2018-07-01)

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
per: Guay, KP, et al.
Publicat: (2023)

Ethylene Induced by Sound Stimulation Enhances Anthocyanin Accumulation in Grape Berry Skin through Direct Upregulation of UDP-Glucose: Flavonoid 3-<i>O</i>-Glucosyltransferase
per: Mone Yamazaki, et al.
Publicat: (2021-10-01)

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
per: Caputo, A, et al.
Publicat: (2016)

Bypass of quality control in protein folding pathways induces specific misfolding of HIV envelope V2 loop: implications for iminosugars as antivirals
per: Spiro, S, et al.
Publicat: (2014)

Inter-domain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
per: Roversi, P, et al.
Publicat: (2017)

Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint
per: Alessandro T. Caputo, et al.
Publicat: (2022-12-01)

A single Caenorhabditis elegans Golgi apparatus-type transporter of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine.
per: Caffaro, C, et al.
Publicat: (2008)

Protein misfolding /
per: O'Doherty, Cian B., et al.
Publicat: (c200)

The findings of glucosyltransferase enzymes derived from oral streptococci
per: Tomonori Hoshino, et al.
Publicat: (2022-11-01)

Structural studies of Endoplasmic Reticulum Glucosidase II
per: Caputo, A, et al.
Publicat: (2015)