Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

Familial adenomatous polyposis (FAP) is a dominantly inherited colorectal tumor predisposition that results from germ-line mutations in the APC gene (chromosome 5q21). FAP shows substantial phenotypic variability: classical polyposis patients develop more than 100 colorectal adenomas, whereas those...

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Bibliografiska uppgifter
Huvudupphovsmän:	Sieber, O, Lamlum, H, Crabtree, MD, Rowan, A, Barclay, E, Lipton, L, Hodgson, S, Thomas, H, Neale, K, Phillips, R, Farrington, S, Dunlop, MG, Mueller, H, Bisgaard, M, Bulow, S, Fidalgo, P, Albuquerque, C, Scarano, M, Bodmer, W, Tomlinson, I, Heinimann, K
Materialtyp:	Journal article
Språk:	English
Publicerad:	2002

Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or "multiple" colorectal adenomas.

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