Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)

Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be beneficial for tumor progression and invasiveness. However...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Michl, J, Monterisi, S, White, B, Blaszczak, W, Hulikova, A, Abdullayeva, G, Bridges, E, Yin, Z, Bodmer, W, Swietach, P
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	Cell Press 2023

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