Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-kappaB, thereby blocking the production of pro-inflammatory cytokines. We have solved the cryst...

Podrobná bibliografie
Hlavní autoři:	Graham, S, Bahar, M, Cooray, S, Chen, R, Whalen, D, Abrescia, N, Alderton, D, Owens, R, Stuart, D, Smith, G, Grimes, J
Médium:	Journal article
Jazyk:	English
Vydáno:	Public Library of Science 2008

Podobné jednotky

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.
Autor: Stephen C Graham, a další
Vydáno: (2008-08-01)

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.
Autor: Benfield, C, a další
Vydáno: (2011)

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse
Autor: Bahar Miraghazadeh, a další
Vydáno: (2018-04-01)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Autor: Smith, C, a další
Vydáno: (2001)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Autor: Andreakos, E, a další
Vydáno: (2006)

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.
Autor: Cooray, S, a další
Vydáno: (2007)

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
Autor: Cherukuri Sudhakar, a další
Vydáno: (2009-01-01)

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.
Autor: Nijnik, A, a další
Vydáno: (2003)

Visualization of lymphatic vessels through NF-kappaB activity.
Autor: Saban, MR, a další
Vydáno: (2004)

I-KappaB Expression in Patient with Psoriasis Vulgaris
Autor: Nahed Abdelazeem, a další
Vydáno: (2022-04-01)

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
Autor: Brian K Bednarski, a další
Vydáno: (2009-09-01)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
Autor: Michael Schuliga
Vydáno: (2015-06-01)

Compartimentalized NF-kappaB activity in the axon initial segment
Autor: Prehn Jochen, a další
Vydáno: (2007-03-01)

The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
Autor: Thomas Karrasch, a další
Vydáno: (2007-07-01)

Expression of p52, a non-canonical NF-kappaB transcription factor, is associated with poor ovarian cancer prognosis
Autor: Demetra H. Hufnagel, a další
Vydáno: (2020-09-01)

Inhibition of Apoptosis and NF-kappa B Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence
Autor: de Motes, C, a další
Vydáno: (2011)

An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.
Autor: Chi Zhang, a další
Vydáno: (2006-12-01)

Haploid reporter screens aimed at identification of NF-kappaB regulators
Autor: Lee, Clarissa Ci
Vydáno: (2014)

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Autor: Feldmann, M, a další
Vydáno: (2002)

Memory extinction entails the inhibition of the transcription factor NF-kappaB.
Autor: Emiliano Merlo, a další
Vydáno: (2008-01-01)

NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.
Autor: Savita Ayyar, a další
Vydáno: (2007-11-01)

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
Autor: Anna Okvist, a další
Vydáno: (2007-09-01)

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
Autor: Laurie T Krug, a další
Vydáno: (2016-08-01)

Inflammatory response in a rat model of gastroschisis is associated with an increase of NF-kappaB
Autor: L. Sbragia, a další
Vydáno: (2010-02-01)

Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro
Autor: D Widera, a další
Vydáno: (2006-05-01)

How vaccinia virus has evolved to subvert the host immune response.
Autor: Bahar, M, a další
Vydáno: (2011)

How vaccinia virus has evolved to subvert the host immune response
Autor: Bahar, M, a další
Vydáno: (2011)

Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis
Autor: Xiaoyu Huang, a další
Vydáno: (2025-01-01)

The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.
Autor: Virginie Ropars, a další
Vydáno: (2009-08-01)

TWEAK/Fn14 and non-canonical NF-kappaB signaling in kidney disease
Autor: Jonay ePoveda, a další
Vydáno: (2013-12-01)

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
Autor: Gyrd-Hansen, M, a další
Vydáno: (2010)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
Autor: Andreakos, E, a další
Vydáno: (2005)

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
Autor: Brummelkamp, T, a další
Vydáno: (2003)

NF-kappaB regulates androgen receptor expression and prostate cancer growth.
Autor: Zhang, L, a další
Vydáno: (2009)

Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis.
Autor: Monaco, C, a další
Vydáno: (2004)

Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
Autor: Bettina Sehnert, a další
Vydáno: (2020-07-01)

Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB
Autor: Solomon Leigh A, a další
Vydáno: (2008-11-01)

NF-kappaB mediated transcriptional repression of acid modifying hormone gastrin.
Autor: Dipanjana Datta De, a další
Vydáno: (2013-01-01)

Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway
Autor: Jing Nianshui, a další
Vydáno: (2019-09-01)

NF-kappaB signaling pathways in Neurological inflammation: A mini review
Autor: Ruey-Horng eShih, a další
Vydáno: (2015-12-01)