Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

Vaccinia virus (VACV), the prototype poxvirus, encodes numerous proteins that modulate the host response to infection. Two such proteins, B14 and A52, act inside infected cells to inhibit activation of NF-kappaB, thereby blocking the production of pro-inflammatory cytokines. We have solved the cryst...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Graham, S, Bahar, M, Cooray, S, Chen, R, Whalen, D, Abrescia, N, Alderton, D, Owens, R, Stuart, D, Smith, G, Grimes, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Public Library of Science 2008

Những quyển sách tương tự

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.
Bằng: Stephen C Graham, et al.
Được phát hành: (2008-08-01)

Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB.
Bằng: Benfield, C, et al.
Được phát hành: (2011)

Nuclear Factor-kappaB in Autoimmunity: Man and Mouse
Bằng: Bahar Miraghazadeh, et al.
Được phát hành: (2018-04-01)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Bằng: Smith, C, et al.
Được phát hành: (2001)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Bằng: Andreakos, E, et al.
Được phát hành: (2006)

Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein.
Bằng: Cooray, S, et al.
Được phát hành: (2007)

NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
Bằng: Cherukuri Sudhakar, et al.
Được phát hành: (2009-01-01)

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.
Bằng: Nijnik, A, et al.
Được phát hành: (2003)

Visualization of lymphatic vessels through NF-kappaB activity.
Bằng: Saban, MR, et al.
Được phát hành: (2004)

I-KappaB Expression in Patient with Psoriasis Vulgaris
Bằng: Nahed Abdelazeem, et al.
Được phát hành: (2022-04-01)

Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin.
Bằng: Brian K Bednarski, et al.
Được phát hành: (2009-09-01)

NF-kappaB Signaling in Chronic Inflammatory Airway Disease
Bằng: Michael Schuliga
Được phát hành: (2015-06-01)

Compartimentalized NF-kappaB activity in the axon initial segment
Bằng: Prehn Jochen, et al.
Được phát hành: (2007-03-01)

The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.
Bằng: Thomas Karrasch, et al.
Được phát hành: (2007-07-01)

Expression of p52, a non-canonical NF-kappaB transcription factor, is associated with poor ovarian cancer prognosis
Bằng: Demetra H. Hufnagel, et al.
Được phát hành: (2020-09-01)

Inhibition of Apoptosis and NF-kappa B Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence
Bằng: de Motes, C, et al.
Được phát hành: (2011)

An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.
Bằng: Chi Zhang, et al.
Được phát hành: (2006-12-01)

Haploid reporter screens aimed at identification of NF-kappaB regulators
Bằng: Lee, Clarissa Ci
Được phát hành: (2014)

Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Bằng: Feldmann, M, et al.
Được phát hành: (2002)

Memory extinction entails the inhibition of the transcription factor NF-kappaB.
Bằng: Emiliano Merlo, et al.
Được phát hành: (2008-01-01)

NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.
Bằng: Savita Ayyar, et al.
Được phát hành: (2007-11-01)

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
Bằng: Anna Okvist, et al.
Được phát hành: (2007-09-01)

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
Bằng: Laurie T Krug, et al.
Được phát hành: (2016-08-01)

Inflammatory response in a rat model of gastroschisis is associated with an increase of NF-kappaB
Bằng: L. Sbragia, et al.
Được phát hành: (2010-02-01)

Nuclear Factor-kappaB controls the reaggregation of 3D neurosphere cultures in vitro
Bằng: D Widera, et al.
Được phát hành: (2006-05-01)

How vaccinia virus has evolved to subvert the host immune response.
Bằng: Bahar, M, et al.
Được phát hành: (2011)

How vaccinia virus has evolved to subvert the host immune response
Bằng: Bahar, M, et al.
Được phát hành: (2011)

Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis
Bằng: Xiaoyu Huang, et al.
Được phát hành: (2025-01-01)

The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.
Bằng: Virginie Ropars, et al.
Được phát hành: (2009-08-01)

TWEAK/Fn14 and non-canonical NF-kappaB signaling in kidney disease
Bằng: Jonay ePoveda, et al.
Được phát hành: (2013-12-01)

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.
Bằng: Gyrd-Hansen, M, et al.
Được phát hành: (2010)

The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
Bằng: Andreakos, E, et al.
Được phát hành: (2005)

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB.
Bằng: Brummelkamp, T, et al.
Được phát hành: (2003)

NF-kappaB regulates androgen receptor expression and prostate cancer growth.
Bằng: Zhang, L, et al.
Được phát hành: (2009)

Nuclear factor kappaB: a potential therapeutic target in atherosclerosis and thrombosis.
Bằng: Monaco, C, et al.
Được phát hành: (2004)

Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases
Bằng: Bettina Sehnert, et al.
Được phát hành: (2020-07-01)

Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB
Bằng: Solomon Leigh A, et al.
Được phát hành: (2008-11-01)

NF-kappaB mediated transcriptional repression of acid modifying hormone gastrin.
Bằng: Dipanjana Datta De, et al.
Được phát hành: (2013-01-01)

Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway
Bằng: Jing Nianshui, et al.
Được phát hành: (2019-09-01)

NF-kappaB signaling pathways in Neurological inflammation: A mini review
Bằng: Ruey-Horng eShih, et al.
Được phát hành: (2015-12-01)