Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes.

Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes.

Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in th...

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Detalles Bibliográficos
Main Authors: Komatsu, H, Lauer, G, Pybus, O, Ouchi, K, Wong, D, Ward, S, Walker, B, Klenerman, P
Formato: Journal article
Idioma:English
Publicado: 2006

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