HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that plays a crucial role in mediating cellular responses to oxygen. Oxygen availability influences multiple steps in HIF activation and recent studies have indicated that at least two steps in this process are governed by a nove...

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Bibliografiske detaljer
Main Authors:	Masson, N, Ratcliffe, P
Format:	Journal article
Sprog:	English
Udgivet:	2003

Lignende værker

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
af: Chan, M, et al.
Udgivet: (2016)

Regulation of HIF: prolyl hydroxylases.
af: Stolze, I, et al.
Udgivet: (2006)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
af: Mole, D, et al.
Udgivet: (2003)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
af: McNeill, L, et al.
Udgivet: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
af: Tuckerman, JR, et al.
Udgivet: (2004)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
af: Schlemminger, I, et al.
Udgivet: (2003)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
af: Masson, N, et al.
Udgivet: (2004)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
af: Cockman, M, et al.
Udgivet: (2019)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
af: Cockman, M, et al.
Udgivet: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
af: Chowdhury, R, et al.
Udgivet: (2016)

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
af: Tian, Y, et al.
Udgivet: (2006)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
af: Yeh, TL, et al.
Udgivet: (2017)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
af: Chowdhury, R, et al.
Udgivet: (2013)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
af: Wijeyekoon, JB
Udgivet: (2013)

Prolyl hydroxylases and therapeutics.
af: Smith, T, et al.
Udgivet: (2010)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
af: Yeoh, K, et al.
Udgivet: (2013)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
af: Willam, C, et al.
Udgivet: (2006)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
af: Lippl, K
Udgivet: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
af: Takahiro Kambara, et al.
Udgivet: (2024-03-01)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
af: Holt-Martyn, JP, et al.
Udgivet: (2019)

Oxygen sensing by HIF hydroxylases.
af: Schofield, C, et al.
Udgivet: (2004)

Signalling hypoxia by HIF hydroxylases.
af: Schofield, C, et al.
Udgivet: (2005)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
af: Foxler, D, et al.
Udgivet: (2012)

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2
af: Kearney, L
Udgivet: (2015)

The HIF hydroxylase pathway and the tumour microenvironment
af: Ratcliffe, P
Udgivet: (2008)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
af: Hewitson, K, et al.
Udgivet: (2007)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
af: Chen, R, et al.
Udgivet: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
af: Chen, R, et al.
Udgivet: (2014)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
af: Flashman, E, et al.
Udgivet: (2010)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
af: Astuti, D, et al.
Udgivet: (2011)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
af: Mayer, M, et al.
Udgivet: (2018)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
af: Astuti, D, et al.
Udgivet: (2010)

miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga.
af: Ana Laura De Lella Ezcurra, et al.
Udgivet: (2016-05-01)

Differential prolyl hydroxylation by six Physcomitrella prolyl-4 hydroxylases
af: Christine Rempfer, et al.
Udgivet: (2024-12-01)

Substrate selectivity of prolyl hydroxylases
af: McDonough, M
Udgivet: (2018)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
af: Stolze, I, et al.
Udgivet: (2004)

Synthesis And Characterization Of Potential Human Hypoxia Inducible Factor (Hif) Prolyl Hydroxylase Domain 2 (Phd-2) Inhibitors
af: Toh, Lee Roy
Udgivet: (2021)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
af: Giatromanolaki, A, et al.
Udgivet: (2008)

Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway
af: Giatromanolaki, A, et al.
Udgivet: (2008)

Structural and mechanistic studies on prolyl hydroxylases
af: Chowdhury, R
Udgivet: (2008)