Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma.

The phenotype and function of cells enriched in tumor-propagating activity and their relationship to the phenotypic architecture in multiple myeloma (MM) are controversial. Here, in a cohort of 30 patients, we show that MM composes 4 hierarchically organized, clonally related subpopulations, which,...

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Detalhes bibliográficos
Principais autores: Chaidos, A, Barnes, C, Cowan, G, May, P, Melo, V, Hatjiharissi, E, Papaioannou, M, Harrington, H, Doolittle, H, Terpos, E, Dimopoulos, M, Abdalla, S, Yarranton, H, Naresh, K, Foroni, L, Reid, A, Rahemtulla, A, Stumpf, M, Roberts, I, Karadimitris, A
Formato: Journal article
Idioma:English
Publicado em: American Society of Hematology 2013