Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BACKGROUND: Common single-nucleotide polymorphisms (SNPs) in ten chromosomal loci have been shown to predispose to colorectal cancer (CRC) in genome-wide association studies. A plausible biological mechanism of CRC susceptibility associated with genetic variation has so far only been proposed for t...

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Bibliografiske detaljer
Main Authors: Niittymäki, I, Tuupanen, S, Li, Y, Järvinen, H, Mecklin, J, Tomlinson, I, Houlston, R, Karhu, A, Aaltonen, L
Format: Journal article
Sprog:English
Udgivet: BioMed Central 2011