Statistical challenges in the detection of mutation and variation using high throughput sequencing

The aim of this thesis is to obtain a better understanding of mutation rates within as well as between the genomes of humans and chimpanzees using data generated by high throughput sequencers. I will start with a review of the field and an overview of the technologies and protocols used to generate...

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Autor principal: Pfeifer, S
Altres autors: McVean, G
Format: Thesis
Idioma:English
Publicat: 2012
Matèries: