Mast cell tetrahydrobiopterin contributes to itch in mice

Mast cell tetrahydrobiopterin contributes to itch in mice

GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is assoc...

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Bibliographic Details
Main Authors:	Zschiebsch, K, Fischer, C, Wilken-Schmitz, A, Geisslinger, G, Channon, K, Watschinger, K, Tegeder, I
Format:	Journal article
Language:	English
Published:	Wiley 2018

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