Bilateral generic working memory circuit requires left-lateralized addition for verbal processing.
According to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM--left; spatial WM--right) ha...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797100524780126208 |
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| author | Ray, M Mackay, C Harmer, C Crow, T |
| author_facet | Ray, M Mackay, C Harmer, C Crow, T |
| author_sort | Ray, M |
| collection | OXFORD |
| description | According to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM--left; spatial WM--right) has been challenged by the position that a common bilateral frontoparietal network subserves both domains. Here, we test the hypothesis that there is a generic WM circuit that recruits additional specialized regions for verbal and spatial processing. We designed a functional magnetic resonance imaging paradigm to elicit activation in the WM circuit for verbal and spatial information using identical stimuli and applied this in 33 healthy controls. We detected left-lateralized quantitative differences in the left frontal and temporal lobe for verbal > spatial WM but no areas of activation for spatial > verbal WM. We speculate that spatial WM is analogous to a "generic" bilateral frontoparietal WM circuit we inherited from our great ape ancestors that evolved, by recruitment of additional left-lateralized frontal and temporal regions, to accommodate language. |
| first_indexed | 2024-03-07T05:38:47Z |
| format | Journal article |
| id | oxford-uuid:e4db561d-dd56-4199-ba54-28086b31309b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:38:47Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:e4db561d-dd56-4199-ba54-28086b31309b2022-03-27T10:19:31ZBilateral generic working memory circuit requires left-lateralized addition for verbal processing.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e4db561d-dd56-4199-ba54-28086b31309bEnglishSymplectic Elements at Oxford2008Ray, MMackay, CHarmer, CCrow, TAccording to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM--left; spatial WM--right) has been challenged by the position that a common bilateral frontoparietal network subserves both domains. Here, we test the hypothesis that there is a generic WM circuit that recruits additional specialized regions for verbal and spatial processing. We designed a functional magnetic resonance imaging paradigm to elicit activation in the WM circuit for verbal and spatial information using identical stimuli and applied this in 33 healthy controls. We detected left-lateralized quantitative differences in the left frontal and temporal lobe for verbal > spatial WM but no areas of activation for spatial > verbal WM. We speculate that spatial WM is analogous to a "generic" bilateral frontoparietal WM circuit we inherited from our great ape ancestors that evolved, by recruitment of additional left-lateralized frontal and temporal regions, to accommodate language. |
| spellingShingle | Ray, M Mackay, C Harmer, C Crow, T Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title_full | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title_fullStr | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title_full_unstemmed | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title_short | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing. |
| title_sort | bilateral generic working memory circuit requires left lateralized addition for verbal processing |
| work_keys_str_mv | AT raym bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT mackayc bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT harmerc bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT crowt bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing |