An intronic Runx1 enhancer directs transcription to the emerging hematopoietic system of the mouse embryo

An intronic Runx1 enhancer directs transcription to the emerging hematopoietic system of the mouse embryo

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Nottingham, W, Burgess, M, Speck, C, Barton, D, Kong-a-san, J, Li, P, Sloane-Stanley, J, Sharpe, J, De Bruijn, M
Formáid:	Conference item
Foilsithe / Cruthaithe:	2007

Míreanna comhchosúla

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.
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The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
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Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.
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DISTINCT RUNX1 ENHANCERS DIRECT TRANSCRIPTION TO DISCRETE STAGES OF DEVELOPMENTAL HEMATOPOIESIS
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Isolation and analysis of hematopoietic stem cells from mouse embryos.
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THE RUNX1+23 ENHANCER IS ACTIVE IN CELLS WITH BOTH ENDOTHELIAL AND HEMATOPOIETIC CHARACTERISTICS DURING MOUSE DEVELOPMENTAL HEMATOPOIESIS
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Runx1 loss minimally impacts long-term hematopoietic stem cells.
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Alternative Runx1 promoter usage in mouse developmental hematopoiesis.
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Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo.
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Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
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Using RUNX1 enhancer-reporter transgenic mouse models to dissect discrete stages of developmental hematopoiesis
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Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
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Differences in the patterns of transcription factor binding in the human and mouse alpha globin clusters point to potential differences in their regulation.
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The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.
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Molecular characterization of the mouse superior lateral parabrachial nucleus through expression of the transcription factor Runx1.
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Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
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Identification of a novel long non-coding RNA within RUNX1 intron 5
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The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia
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Runx transcription factors in neuronal development
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Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.
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Wip1 regulates hematopoietic stem cell development in the mouse embryo
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RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors
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RUNX1 Mutations in Inherited and Sporadic Leukemia
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RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia
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Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos.
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Detained introns are a novel, widespread class of post-transcriptionally spliced introns
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Identification of Introns by Reverse-Transcription PCR
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Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
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A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
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RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance
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CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition
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Runx1 promotes proliferation and neuronal differentiation in adult mouse neurosphere cultures
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Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network
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Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model.
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