Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion.

Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretion.

AIMS/HYPOTHESIS: Glucose-stimulated insulin secretion is dependent on the electrical activity of beta cells; hence, genes encoding beta cell ion channels are potential candidate genes for type 2 diabetes. The gene encoding the voltage-dependent Ca(2+) channel Ca(V)2.3 (CACNA1E), telomeric to a regio...

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Những tác giả chính: Holmkvist, J, Tojjar, D, Almgren, P, Lyssenko, V, Lindgren, C, Isomaa, B, Tuomi, T, Berglund, G, Renström, E, Groop, L
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2007

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