Inhibition of tryptophan-dioxygenase activity increases the antitumor efficacy of immune checkpoint inhibitors

Inhibition of tryptophan-dioxygenase activity increases the antitumor efficacy of immune checkpoint inhibitors

Tryptophan 2,3-dioxygenase (TDO) is an enzyme that degrades tryptophan into kynurenine and thereby induces immunosuppression. Like indoleamine 2,3-dioxygenase (IDO1), TDO is considered as a relevant drug target to improve the efficacy of cancer immunotherapy. However, its role in various immunothera...

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Detalhes bibliográficos
Principais autores:	Schramme, F, Crosignani, S, Frederix, K, Hoffmann, D, Pilotte, L, Stroobant, V, Preillon, J, Driessens, G, Van Den Eynde, B
Formato:	Journal article
Idioma:	English
Publicado em:	American Association for Cancer Research 2019

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