Cholesterol and the risk of renal dysfunction in apparently healthy men.
Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2003
|
| _version_ | 1797100574464802816 |
|---|---|
| author | Schaeffner, E Kurth, T Curhan, G Glynn, R Rexrode, K Baigent, C Buring, J Gaziano, J |
| author_facet | Schaeffner, E Kurth, T Curhan, G Glynn, R Rexrode, K Baigent, C Buring, J Gaziano, J |
| author_sort | Schaeffner, E |
| collection | OXFORD |
| description | Despite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as <!--=55 ml/min. Cholesterol parameters included total cholesterol (<200, 200 to 239, and -->/= 240 mg/dl), HDL (<40 or >/= 40 mg/dl), total non-HDL cholesterol, and the ratio of total cholesterol to HDL. We used logistic regression to calculate age- and multivariable adjusted odds ratios as a measure for the relative risk. After 14 yr, 134 men (3.0%) had elevated creatinine and 244 (5.4%) had reduced creatinine clearance. The multivariable relative risk for elevated creatinine was 1.77 (95% confidence interval [CI], 1.10 to 2.86) for total cholesterol >/= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL <40 mg/dl, 2.34 (95% CI, 1.34 to 4.07) for the highest quartile of total cholesterol/HDL ratio (>/= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine <1.5 mg/dl. |
| first_indexed | 2024-03-07T05:39:28Z |
| format | Journal article |
| id | oxford-uuid:e50f8d4c-ad3b-4d02-8a22-d1e7209d335b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:39:28Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:e50f8d4c-ad3b-4d02-8a22-d1e7209d335b2022-03-27T10:21:14ZCholesterol and the risk of renal dysfunction in apparently healthy men.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e50f8d4c-ad3b-4d02-8a22-d1e7209d335bEnglishSymplectic Elements at Oxford2003Schaeffner, EKurth, TCurhan, GGlynn, RRexrode, KBaigent, CBuring, JGaziano, JDespite extensive knowledge about abnormal lipid patterns in patients with end-stage renal disease, the association between cholesterol and the development of renal dysfunction is unclear. We evaluated this association in a prospective cohort study among 4,483 initially healthy men participating in the Physicians' Health Study who provided blood samples in 1982 and 1996. Main outcome measures were elevated creatinine, defined as >/= 1.5 mg/dl (133 micromol/L), and reduced estimated creatinine clearance, defined as <!--=55 ml/min. Cholesterol parameters included total cholesterol (<200, 200 to 239, and -->/= 240 mg/dl), HDL (<40 or >/= 40 mg/dl), total non-HDL cholesterol, and the ratio of total cholesterol to HDL. We used logistic regression to calculate age- and multivariable adjusted odds ratios as a measure for the relative risk. After 14 yr, 134 men (3.0%) had elevated creatinine and 244 (5.4%) had reduced creatinine clearance. The multivariable relative risk for elevated creatinine was 1.77 (95% confidence interval [CI], 1.10 to 2.86) for total cholesterol >/= 240 mg/dl, 2.16 (95% CI, 1.42 to 3.27) for HDL <40 mg/dl, 2.34 (95% CI, 1.34 to 4.07) for the highest quartile of total cholesterol/HDL ratio (>/= >6.8), and 2.16 (95% CI, 1.22 to 3.80) for the highest quartile of non-HDL cholesterol (>/= 196.1). Similar although smaller associations were observed between cholesterol parameters and reduced creatinine clearance. Elevated total cholesterol, high non-HDL cholesterol, a high ratio of total cholesterol/HDL, and low HDL in particular were significantly associated with an increased risk of developing renal dysfunction in men with an initial creatinine <1.5 mg/dl. |
| spellingShingle | Schaeffner, E Kurth, T Curhan, G Glynn, R Rexrode, K Baigent, C Buring, J Gaziano, J Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title | Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title_full | Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title_fullStr | Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title_full_unstemmed | Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title_short | Cholesterol and the risk of renal dysfunction in apparently healthy men. |
| title_sort | cholesterol and the risk of renal dysfunction in apparently healthy men |
| work_keys_str_mv | AT schaeffnere cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT kurtht cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT curhang cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT glynnr cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT rexrodek cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT baigentc cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT buringj cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen AT gazianoj cholesterolandtheriskofrenaldysfunctioninapparentlyhealthymen |