Early antiretroviral therapy reduces hiv dna following perinatal HIV infection

Early antiretroviral therapy reduces hiv dna following perinatal HIV infection

: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression...

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Bibliografiske detaljer
Main Authors: Foster, C, Pace, M, Kaye, S, Hopkins, E, Jones, M, Robinson, N, Fidler, S, Frater, J, CHERUB Investigators
Format: Journal article
Sprog:English
Udgivet: Lippincott, Williams & Wilkins 2017
Beskrivelse
Summary:: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression on ART for >5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (p = 0.0062), and correlated with age of initiation (p = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (p = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

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