The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria
Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1826310137921404928 |
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| author | Srinamon, K Watson, JA Silamut, K Intharabut, B Phu, NH Diep, PT Lyke, KE Fanello, C von Seidlein, L Chotivanich, K Dondorp, AM Day, NPJ White, NJ |
| author_facet | Srinamon, K Watson, JA Silamut, K Intharabut, B Phu, NH Diep, PT Lyke, KE Fanello, C von Seidlein, L Chotivanich, K Dondorp, AM Day, NPJ White, NJ |
| author_sort | Srinamon, K |
| collection | OXFORD |
| description | Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality. In African children the proportion of pigment containing PMNs helps distinguish severe malaria from other life-threatening febrile illnesses, and it adds to the prognostic assessment from simple bedside examination, and to the conventional malaria parasite count. Microscopy assessment of pigment containing PMNs is simple and rapid, and should be performed in all patients hospitalised with suspected severe malaria. |
| first_indexed | 2024-03-07T07:47:40Z |
| format | Journal article |
| id | oxford-uuid:e52f042d-2a83-46ba-a66d-82896c6a6fd2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:47:40Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:e52f042d-2a83-46ba-a66d-82896c6a6fd22023-06-09T14:01:08ZThe prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malariaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e52f042d-2a83-46ba-a66d-82896c6a6fd2EnglishSymplectic ElementsSpringer Nature2022Srinamon, KWatson, JASilamut, KIntharabut, BPhu, NHDiep, PTLyke, KEFanello, Cvon Seidlein, LChotivanich, KDondorp, AMDay, NPJWhite, NJSevere falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality. In African children the proportion of pigment containing PMNs helps distinguish severe malaria from other life-threatening febrile illnesses, and it adds to the prognostic assessment from simple bedside examination, and to the conventional malaria parasite count. Microscopy assessment of pigment containing PMNs is simple and rapid, and should be performed in all patients hospitalised with suspected severe malaria. |
| spellingShingle | Srinamon, K Watson, JA Silamut, K Intharabut, B Phu, NH Diep, PT Lyke, KE Fanello, C von Seidlein, L Chotivanich, K Dondorp, AM Day, NPJ White, NJ The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title | The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title_full | The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title_fullStr | The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title_full_unstemmed | The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title_short | The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
| title_sort | prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria |
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