Site-selective modification of peptides using rhodium and palladium catalysis: complementary electrophilic and nucleophilic arylation.

The site-selective modification of peptides containing dehydroalanine, tyrosine and tryptophan residues has been achieved using rhodium catalysed conjugate additions or palladium catalysed aryl-amination and -etherification reactions.

Detalhes bibliográficos
Main Authors: Chapman, C, Matsuno, A, Frost, C, Willis, M
Formato: Journal article
Idioma:English
Publicado em: 2007
Descrição
Resumo:The site-selective modification of peptides containing dehydroalanine, tyrosine and tryptophan residues has been achieved using rhodium catalysed conjugate additions or palladium catalysed aryl-amination and -etherification reactions.