The African coelacanth genome provides insights into tetrapod evolution.
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors...
| Príomhchruthaitheoirí: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formáid: | Journal article |
| Teanga: | English |
| Foilsithe / Cruthaithe: |
2013
|
| _version_ | 1826301945355173888 |
|---|---|
| author | Amemiya, C Alföldi, J Lee, A Fan, S Philippe, H Maccallum, I Braasch, I Manousaki, T Schneider, I Rohner, N Organ, C Chalopin, D Smith, J Robinson, M Dorrington, R Gerdol, M Aken, B Biscotti, M Barucca, M Baurain, D Berlin, A Blatch, G Buonocore, F Burmester, T Campbell, MS |
| author_facet | Amemiya, C Alföldi, J Lee, A Fan, S Philippe, H Maccallum, I Braasch, I Manousaki, T Schneider, I Rohner, N Organ, C Chalopin, D Smith, J Robinson, M Dorrington, R Gerdol, M Aken, B Biscotti, M Barucca, M Baurain, D Berlin, A Blatch, G Buonocore, F Burmester, T Campbell, MS |
| author_sort | Amemiya, C |
| collection | OXFORD |
| description | The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution. |
| first_indexed | 2024-03-07T05:40:03Z |
| format | Journal article |
| id | oxford-uuid:e5433eef-4b47-449b-a4b4-baeeb25a374d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:40:03Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:e5433eef-4b47-449b-a4b4-baeeb25a374d2022-03-27T10:22:40ZThe African coelacanth genome provides insights into tetrapod evolution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e5433eef-4b47-449b-a4b4-baeeb25a374dEnglishSymplectic Elements at Oxford2013Amemiya, CAlföldi, JLee, AFan, SPhilippe, HMaccallum, IBraasch, IManousaki, TSchneider, IRohner, NOrgan, CChalopin, DSmith, JRobinson, MDorrington, RGerdol, MAken, BBiscotti, MBarucca, MBaurain, DBerlin, ABlatch, GBuonocore, FBurmester, TCampbell, MSThe discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features. Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues show the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution. |
| spellingShingle | Amemiya, C Alföldi, J Lee, A Fan, S Philippe, H Maccallum, I Braasch, I Manousaki, T Schneider, I Rohner, N Organ, C Chalopin, D Smith, J Robinson, M Dorrington, R Gerdol, M Aken, B Biscotti, M Barucca, M Baurain, D Berlin, A Blatch, G Buonocore, F Burmester, T Campbell, MS The African coelacanth genome provides insights into tetrapod evolution. |
| title | The African coelacanth genome provides insights into tetrapod evolution. |
| title_full | The African coelacanth genome provides insights into tetrapod evolution. |
| title_fullStr | The African coelacanth genome provides insights into tetrapod evolution. |
| title_full_unstemmed | The African coelacanth genome provides insights into tetrapod evolution. |
| title_short | The African coelacanth genome provides insights into tetrapod evolution. |
| title_sort | african coelacanth genome provides insights into tetrapod evolution |
| work_keys_str_mv | AT amemiyac theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT alfoldij theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT leea theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT fans theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT philippeh theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT maccallumi theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT braaschi theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT manousakit theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT schneideri theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT rohnern theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT organc theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT chalopind theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT smithj theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT robinsonm theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT dorringtonr theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT gerdolm theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT akenb theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT biscottim theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT baruccam theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT bauraind theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT berlina theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT blatchg theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT buonocoref theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT burmestert theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT campbellms theafricancoelacanthgenomeprovidesinsightsintotetrapodevolution AT amemiyac africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT alfoldij africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT leea africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT fans africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT philippeh africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT maccallumi africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT braaschi africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT manousakit africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT schneideri africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT rohnern africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT organc africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT chalopind africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT smithj africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT robinsonm africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT dorringtonr africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT gerdolm africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT akenb africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT biscottim africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT baruccam africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT bauraind africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT berlina africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT blatchg africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT buonocoref africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT burmestert africancoelacanthgenomeprovidesinsightsintotetrapodevolution AT campbellms africancoelacanthgenomeprovidesinsightsintotetrapodevolution |