Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).
A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with...
| Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2014
|
| _version_ | 1826301955247439872 |
|---|---|
| author | Aleksandrova, K Jenab, M Bueno-de-Mesquita, H Fedirko, V Kaaks, R Lukanova, A van Duijnhoven, F Jansen, E Rinaldi, S Romieu, I Ferrari, P Murphy, N Gunter, M Riboli, E Westhpal, S Overvad, K Tjønneland, A Halkjær, J Boutron-Ruault, M Dossus, L Racine, A Trichopoulou, A Bamia, C Orfanos, P Agnoli, C |
| author_facet | Aleksandrova, K Jenab, M Bueno-de-Mesquita, H Fedirko, V Kaaks, R Lukanova, A van Duijnhoven, F Jansen, E Rinaldi, S Romieu, I Ferrari, P Murphy, N Gunter, M Riboli, E Westhpal, S Overvad, K Tjønneland, A Halkjær, J Boutron-Ruault, M Dossus, L Racine, A Trichopoulou, A Bamia, C Orfanos, P Agnoli, C |
| author_sort | Aleksandrova, K |
| collection | OXFORD |
| description | A number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60 % of the overall biomarker variance. In multivariable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95 % CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95 % CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95 % CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95 % CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as biomarker patterns representing potentially important pathways for CRC development. |
| first_indexed | 2024-03-07T05:40:10Z |
| format | Journal article |
| id | oxford-uuid:e54cdbb3-f7a2-434b-b531-33c1b10347a8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:40:10Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:e54cdbb3-f7a2-434b-b531-33c1b10347a82022-03-27T10:23:02ZBiomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e54cdbb3-f7a2-434b-b531-33c1b10347a8EnglishSymplectic Elements at Oxford2014Aleksandrova, KJenab, MBueno-de-Mesquita, HFedirko, VKaaks, RLukanova, Avan Duijnhoven, FJansen, ERinaldi, SRomieu, IFerrari, PMurphy, NGunter, MRiboli, EWesthpal, SOvervad, KTjønneland, AHalkjær, JBoutron-Ruault, MDossus, LRacine, ATrichopoulou, ABamia, COrfanos, PAgnoli, CA number of biomarkers of inflammatory and metabolic pathways are individually related to higher risk of colorectal cancer (CRC); however, the association between biomarker patterns and CRC incidence has not been previously evaluated. Our study investigates the association of biomarker patterns with CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). During median follow-up time of 7.0 (3.7-9.4) years, 1,260 incident CRC cases occurred and were matched to 1,260 controls using risk-set sampling. Pre-diagnostic measurements of C-peptide, glycated hemoglobin, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), reactive oxygen metabolites (ROM), insulin-like growth factor 1, adiponectin, leptin and soluble leptin receptor (sOB-R) were used to derive biomarker patterns from principal component analysis (PCA). The relation with CRC incidence was assessed using conditional logistic regression models. We identified four biomarker patterns 'HDL-C/Adiponectin fractions', 'ROM/CRP', 'TG/C-peptide' and 'leptin/sOB-R' to explain 60 % of the overall biomarker variance. In multivariable-adjusted logistic regression, the 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' patterns were associated with CRC risk [for the highest quartile vs the lowest, incidence rate ratio (IRR) = 0.69, 95 % CI 0.51-0.93, P-trend = 0.01; IRR = 1.70, 95 % CI 1.30-2.23, P-trend = 0.002; and IRR = 0.79, 95 % CI 0.58-1.07; P-trend = 0.05, respectively]. In contrast, the 'TG/C-peptide' pattern was not associated with CRC risk (IRR = 0.75, 95 % CI 0.56-1.00, P-trend = 0.24). After cases within the first 2 follow-up years were excluded, the 'ROM/CRP' pattern was no longer associated with CRC risk, suggesting potential influence of preclinical disease on these associations. By application of PCA, the study identified 'HDL-C/Adiponectin fractions', 'ROM/CRP' and 'leptin/sOB-R' as biomarker patterns representing potentially important pathways for CRC development. |
| spellingShingle | Aleksandrova, K Jenab, M Bueno-de-Mesquita, H Fedirko, V Kaaks, R Lukanova, A van Duijnhoven, F Jansen, E Rinaldi, S Romieu, I Ferrari, P Murphy, N Gunter, M Riboli, E Westhpal, S Overvad, K Tjønneland, A Halkjær, J Boutron-Ruault, M Dossus, L Racine, A Trichopoulou, A Bamia, C Orfanos, P Agnoli, C Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title | Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full | Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_fullStr | Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_full_unstemmed | Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_short | Biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). |
| title_sort | biomarker patterns of inflammatory and metabolic pathways are associated with risk of colorectal cancer results from the european prospective investigation into cancer and nutrition epic |
| work_keys_str_mv | AT aleksandrovak biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT jenabm biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT buenodemesquitah biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT fedirkov biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT kaaksr biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT lukanovaa biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT vanduijnhovenf biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT jansene biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT rinaldis biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT romieui biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT ferrarip biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT murphyn biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT gunterm biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT ribolie biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT westhpals biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT overvadk biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT tjønnelanda biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT halkjærj biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT boutronruaultm biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT dossusl biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT racinea biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT trichopouloua biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT bamiac biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT orfanosp biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic AT agnolic biomarkerpatternsofinflammatoryandmetabolicpathwaysareassociatedwithriskofcolorectalcancerresultsfromtheeuropeanprospectiveinvestigationintocancerandnutritionepic |