Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

Hiển thị phiên bản (1) khác

The response of animals to hypoxia is mediated by the hypoxia-inducible transcription factor. Human hypoxia-inducible factor is regulated by four Fe(II)- and 2-oxoglutarate-dependent oxygenases: prolyl hydroxylase domain enzymes 1-3 catalyse hydroxylation of two prolyl-residues in hypoxia-inducible...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Flashman, E, Hoffart, L, Hamed, R, Bollinger, J, Krebs, C, Schofield, C
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2010

Những quyển sách tương tự

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
Bằng: Flashman, E, et al.
Được phát hành: (2010)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
Bằng: Tarhonskaya, H, et al.
Được phát hành: (2014)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Bằng: Chowdhury, R, et al.
Được phát hành: (2009)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
Bằng: Flashman, E, et al.
Được phát hành: (2010)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
Bằng: Chowdhury, R, et al.
Được phát hành: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Bằng: Chowdhury, R, et al.
Được phát hành: (2011)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
Bằng: McDonough, M, et al.
Được phát hành: (2006)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
Bằng: Hewitson, K, et al.
Được phát hành: (2007)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
Bằng: Domene, C, et al.
Được phát hành: (2020)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
Bằng: McNeill, L, et al.
Được phát hành: (2005)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
Bằng: Lippl, K, et al.
Được phát hành: (2015)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
Bằng: Flashman, E, et al.
Được phát hành: (2008)

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha.
Bằng: Willam, C, et al.
Được phát hành: (2004)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
Bằng: Mecinovic, J, et al.
Được phát hành: (2007)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
Bằng: Mecinovic, J, et al.
Được phát hành: (2008)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
Bằng: Abboud, M, et al.
Được phát hành: (2018)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
Bằng: Ehrismann, D, et al.
Được phát hành: (2007)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Bằng: Chowdhury, R, et al.
Được phát hành: (2013)

Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
Bằng: Jie Lun, et al.
Được phát hành: (2023-05-01)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
Bằng: Kiriakidis, S, et al.
Được phát hành: (2017)

Kinetic investigations of the oxygen entry pathway of the hypoxia-inducible factor (HIF) prolyl hydroxylase 2
Bằng: Kearney, L
Được phát hành: (2015)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
Bằng: Mecinović, J, et al.
Được phát hành: (2009)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
Bằng: Chan, M, et al.
Được phát hành: (2016)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
Bằng: Abboud, M, et al.
Được phát hành: (2018)

Bibliometric analysis of hypoxia inducible factor prolyl hydroxylase inhibitor in anemia
Bằng: Li Zheng, et al.
Được phát hành: (2022-09-01)

Inhibition of a viral prolyl hydroxylase
Bằng: Langley, G, et al.
Được phát hành: (2019)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
Bằng: Singh, A, et al.
Được phát hành: (2020)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
Bằng: Lippl, K
Được phát hành: (2018)

Updates on Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors in the Treatment of Renal Anemia
Bằng: Jing Li, et al.
Được phát hành: (2022-10-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Bằng: Chowdhury, R, et al.
Được phát hành: (2016)

Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors
Bằng: Andrey A. Poloznikov, et al.
Được phát hành: (2022-01-01)

Pleotropic effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors: are they clinically relevant?
Bằng: Yu-Hsiang Chou, et al.
Được phát hành: (2023-01-01)

Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications
Bằng: So Yeon Kim, et al.
Được phát hành: (2015-11-01)

Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases
Bằng: Mengqiu Miao, et al.
Được phát hành: (2022-02-01)

Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
Bằng: Chan, MC, et al.
Được phát hành: (2015)

Loss of Endothelial Hypoxia Inducible Factor‐Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis
Bằng: Zhiyu Dai, et al.
Được phát hành: (2021-11-01)

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain.
Bằng: Mun Chiang Chan, et al.
Được phát hành: (2015-01-01)

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
Bằng: Mecinović, J, et al.
Được phát hành: (2008)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
Bằng: Figg, WD, et al.
Được phát hành: (2023)

Prolyl hydroxylases and therapeutics.
Bằng: Smith, T, et al.
Được phát hành: (2010)