Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition.
CC-chemokines are important mediators in the pathogenesis of atherosclerosis. Atherosclerosis progression is reduced by high-level, short-term inhibition of CC-chemokine activity, for example by adenoviral gene transfer. However, atherosclerosis is a chronic condition where short-term effects, while...
Main Authors: | Bursill, C, McNeill, E, Wang, L, Hibbitt, O, Wade-Martins, R, Paterson, D, Greaves, D, Channon, K |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2009
|
Similar Items
-
Adenoviral mediated delivery of a vaccinia viral protein (35K) blocks CC-chemokine activity in vitro and in vivo and may therefore be a useful therapeutic strategy to reduce the initiation and progression of CC-chemokine induced atherosclerosis
by: Bursill, C, et al.
Published: (2003) -
Membrane-bound CC chemokine inhibitor 35K provides localized inhibition of CC chemokine activity in vitro and in vivo.
by: Bursill, C, et al.
Published: (2006) -
Adenoviral delivery of CC-chemokine inhibitor '35K' reduces macrophage recruitment and atherosclerosis in ApoE knockout mice
by: Bursill, C, et al.
Published: (2004) -
Expression of a membrane associated CC-chemokine inhibitor protein reduces in vitro macrophage chemotaxis to CC chemokines
by: McNeill, E, et al.
Published: (2010) -
A membrane-bound vaccinia viral protein 'mem35k' blocks CC-chemokine induced cell migration and CC-chemokine activity in vitro
by: Bursill, C, et al.
Published: (2005)