Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function.
OBJECTIVE: This study tested the hypothesis that degeneration of the corticofugal tracts (CFTs) is related to poor functional outcome in the upper limb after stroke. METHODS: . The authors used diffusion tensor imaging to determine the degree of white matter integrity of the CFT (FA(AH/UH)) in chro...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797100644054597632 |
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| author | Lindberg, P Skejø, P Rounis, E Nagy, Z Schmitz, C Wernegren, H Bring, A Engardt, M Forssberg, H Borg, J |
| author_facet | Lindberg, P Skejø, P Rounis, E Nagy, Z Schmitz, C Wernegren, H Bring, A Engardt, M Forssberg, H Borg, J |
| author_sort | Lindberg, P |
| collection | OXFORD |
| description | OBJECTIVE: This study tested the hypothesis that degeneration of the corticofugal tracts (CFTs) is related to poor functional outcome in the upper limb after stroke. METHODS: . The authors used diffusion tensor imaging to determine the degree of white matter integrity of the CFT (FA(AH/UH)) in chronic stroke patients and controls. The functional integrity of the corticospinal pathway was examined using transcranial magnetic stimulation. Recruitment curves and silent period duration were measured. The relationship between FA(AH/UH) and functional outcome of the upper limb was also assessed using a battery of upper limb function tests. RESULTS: In patients, FA( AH/UH) correlated positively with the slope of recruitment curves (RC(AH/UH)) and grip strength. FA(AH/UH) also correlated negatively with the silent period duration (SP(AH/UH)). According to the FA(AH/UH), patients were also classified into groups with minimal or extensive Wallerian degeneration (WD). Patients with more extensive WD had poorer grip strength, dexterity, and range of movement. CONCLUSIONS: The authors' results suggest that structural and functional integrity of the CFT is essential to maintain function of the upper limb after stroke. |
| first_indexed | 2024-03-07T05:40:30Z |
| format | Journal article |
| id | oxford-uuid:e56752df-b9e8-4633-8837-41dfe08516af |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:40:30Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:e56752df-b9e8-4633-8837-41dfe08516af2022-03-27T10:23:41ZWallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e56752df-b9e8-4633-8837-41dfe08516afEnglishSymplectic Elements at Oxford2007Lindberg, PSkejø, PRounis, ENagy, ZSchmitz, CWernegren, HBring, AEngardt, MForssberg, HBorg, J OBJECTIVE: This study tested the hypothesis that degeneration of the corticofugal tracts (CFTs) is related to poor functional outcome in the upper limb after stroke. METHODS: . The authors used diffusion tensor imaging to determine the degree of white matter integrity of the CFT (FA(AH/UH)) in chronic stroke patients and controls. The functional integrity of the corticospinal pathway was examined using transcranial magnetic stimulation. Recruitment curves and silent period duration were measured. The relationship between FA(AH/UH) and functional outcome of the upper limb was also assessed using a battery of upper limb function tests. RESULTS: In patients, FA( AH/UH) correlated positively with the slope of recruitment curves (RC(AH/UH)) and grip strength. FA(AH/UH) also correlated negatively with the silent period duration (SP(AH/UH)). According to the FA(AH/UH), patients were also classified into groups with minimal or extensive Wallerian degeneration (WD). Patients with more extensive WD had poorer grip strength, dexterity, and range of movement. CONCLUSIONS: The authors' results suggest that structural and functional integrity of the CFT is essential to maintain function of the upper limb after stroke. |
| spellingShingle | Lindberg, P Skejø, P Rounis, E Nagy, Z Schmitz, C Wernegren, H Bring, A Engardt, M Forssberg, H Borg, J Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title | Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title_full | Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title_fullStr | Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title_full_unstemmed | Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title_short | Wallerian degeneration of the corticofugal tracts in chronic stroke: a pilot study relating diffusion tensor imaging, transcranial magnetic stimulation, and hand function. |
| title_sort | wallerian degeneration of the corticofugal tracts in chronic stroke a pilot study relating diffusion tensor imaging transcranial magnetic stimulation and hand function |
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