Structure of the human RECQ1 helicase reveals a putative strand-separation pin.
RecQ-like helicases, which include 5 members in the human genome, are important in maintaining genome integrity. We present a crystal structure of a truncated form of the human RECQ1 protein with Mg-ADP. The truncated protein is active in DNA fork unwinding but lacks other activities of the full-len...
| Auteurs principaux: | , , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
2009
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| Sujets: |