Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.
L-glutamate semialdehyde (L-GSA) is an intermediate in biosynthetic pathways including those leading to the carbapenem antibiotics. We describe studies on asymmetric deuteration or hydrogenation of appropriate didehydro-amino acid precursors for the stereoselective synthesis of C-2- and/or C-3-[2H]-...
Auteurs principaux: | Ducho, C, Hamed, R, Batchelar, E, Sorensen, J, Odell, B, Schofield, C |
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Format: | Journal article |
Langue: | English |
Publié: |
2009
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