Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

L-glutamate semialdehyde (L-GSA) is an intermediate in biosynthetic pathways including those leading to the carbapenem antibiotics. We describe studies on asymmetric deuteration or hydrogenation of appropriate didehydro-amino acid precursors for the stereoselective synthesis of C-2- and/or C-3-[2H]-...

Detaylı Bibliyografya
Asıl Yazarlar:	Ducho, C, Hamed, R, Batchelar, E, Sorensen, J, Odell, B, Schofield, C
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2009

Benzer Materyaller

Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis.
Yazar:: Sorensen, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes
Yazar:: Hamed, R, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.
Yazar:: Sleeman, M, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Regio- and stereoselective synthesis of new diaminocyclopentanols
Yazar:: Evgeni A. Larin, ve diğerleri
Baskı/Yayın Bilgisi: (2014-10-01)

Hydrolases in organic synthesis : regio-and stereoselective biotransformations /
Yazar:: 185258 Bornscheuer, Uwe Theo, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases.
Yazar:: Hamed, R, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

REGIO- AND STEREOSELECTIVE DERIVATISATION OF AN APORPHINE SCAFFOLD
Yazar:: Atkinson, J, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
Yazar:: Zoltán Hujber, ve diğerleri
Baskı/Yayın Bilgisi: (2018-11-01)

Regio- and Stereoselective Synthesis of (Z)-Vinylgermanes by Hydrogermylation of Alkynes
Yazar:: David-Quillot, Frank, ve diğerleri
Baskı/Yayın Bilgisi: (2007-10-01)

The enzymology of clavam and carbapenem biosynthesis.
Yazar:: Kershaw, N, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
Yazar:: Horita, S, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily.
Yazar:: Batchelar, E, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
Yazar:: Hamed, R, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Regio- and stereoselectivity in the Paternò-Büchi reaction on furan derivatives
Yazar:: Maurizio D'Auria, ve diğerleri
Baskı/Yayın Bilgisi: (2006-01-01)

Regio- and stereoselective carbometallation reactions of N-alkynylamides and sulfonamides
Yazar:: Yury Minko, ve diğerleri
Baskı/Yayın Bilgisi: (2013-03-01)

The enzymes of β-lactam biosynthesis.
Yazar:: Hamed, R, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

The enzymes of beta-lactam biosynthesis
Yazar:: Hamed, R, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates
Yazar:: Loránd Kiss, ve diğerleri
Baskı/Yayın Bilgisi: (2013-06-01)

Influence of electrochemical conditions on the regio- and stereoselectivity of selenocyclization of alkenyl hydantoins
Yazar:: Šmit Biljana M., ve diğerleri
Baskı/Yayın Bilgisi: (2021-01-01)

Evolving P450pyr Monooxygenase for Regio- and Stereoselective Hydroxylations
Yazar:: Yi Yang, ve diğerleri
Baskı/Yayın Bilgisi: (2015-03-01)

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).
Yazar:: Sleeman, M, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks
Yazar:: Boris Schmidtgall, ve diğerleri
Baskı/Yayın Bilgisi: (2015-01-01)

Aspartyl Oxidation Catalysts That Dial In Functional Group Selectivity, along with Regio- and Stereoselectivity
Yazar:: Joshua S. Alford, ve diğerleri
Baskı/Yayın Bilgisi: (2016-09-01)

Regio- and stereoselective alkyne difunctionalization by using benziodoxole triflate and phosphate ester
Yazar:: Tan, Ploypailin Siew Ling
Baskı/Yayın Bilgisi: (2021)

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous
Yazar:: Elaine O’Reilly, ve diğerleri
Baskı/Yayın Bilgisi: (2012-04-01)

Regio- and stereoselective functionalization of alkenes with emphasis on mechanistic insight and sustainability concerns
Yazar:: Ghulam Bary, ve diğerleri
Baskı/Yayın Bilgisi: (2021-07-01)

Exploiting Substrate Promiscuity of Ectoine Hydroxylase for Regio- and Stereoselective Modification of Homoectoine
Yazar:: Laura Czech, ve diğerleri
Baskı/Yayın Bilgisi: (2019-11-01)

Succinic Semialdehyde Dehydrogenase Deficiency: An Update
Yazar:: Miroslava Didiasova, ve diğerleri
Baskı/Yayın Bilgisi: (2020-02-01)

Regio- and stereoselective synthesis of new spiro-isoxazolidines via 1,3-dipolar cycloaddition
Yazar:: Nafâa Jegham, ve diğerleri
Baskı/Yayın Bilgisi: (2017-05-01)

Succinic Semialdehyde Dehydrogenase Deficiency in a Chinese Boy
Yazar:: Tay, C.G., ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Deuterated reagents in multicomponent reactions to afford deuterium-labeled products
Yazar:: Kevin Schofield, ve diğerleri
Baskı/Yayın Bilgisi: (2024-09-01)

Dependency of the regio- and stereoselectivity of intramolecular, ring-closing glycosylations upon the ring size
Yazar:: Patrick Claude, ve diğerleri
Baskı/Yayın Bilgisi: (2011-12-01)

Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates
Yazar:: Giorgio Pesciullesi, ve diğerleri
Baskı/Yayın Bilgisi: (2020-09-01)

A Single Nucleotide Substitution of GSAM Gene Causes Massive Accumulation of Glutamate 1-Semialdehyde and Yellow Leaf Phenotype in Rice
Yazar:: Qian Wang, ve diğerleri
Baskı/Yayın Bilgisi: (2021-06-01)

Regio - and stereoselective synthesis of the iminosugars â€“ 4-substituted 1-benzylpiperidine-3,5-diols
Yazar:: Ivan S. Veselov, ve diğerleri
Baskı/Yayın Bilgisi: (2019-02-01)

Synthesis and Characterization of Stable Isotope Deuterium-Labelled Higenamine
Yazar:: HAN Shilei;XU Yin;CHEN Juling;YANG Lifeng;ZHANG Lei
Baskı/Yayın Bilgisi: (2021-08-01)

Site-specific synthesis and application of deuterium-labeled sterols
Yazar:: Hubert Muchalski
Baskı/Yayın Bilgisi: (2016-12-01)

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase
Yazar:: Kaylen R. Meeks, ve diğerleri
Baskı/Yayın Bilgisi: (2024-11-01)

New Chiral P-N Ligands for the Regio- and Stereoselective Pd-Catalyzed Dimerization of Styrene
Yazar:: Sergio Castillon, ve diğerleri
Baskı/Yayın Bilgisi: (2011-02-01)

Highly regio- and stereoselective phosphinylphosphination of terminal alkynes with tetraphenyldiphosphine monoxide under radical conditions
Yazar:: Dat Phuc Tran, ve diğerleri
Baskı/Yayın Bilgisi: (2021-04-01)