Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.

BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha are essential regulatory proteins for the adaptation of tumor cells to hypoxia, and they stimulate angiogenesis through activation of the vascular endothelial growth factor (VEGF) gene. METHODS: HIF-1alpha and HIF-2alpha protei...

Full description

Bibliographic Details
Main Authors:	Sivridis, E, Giatromanolaki, A, Gatter, K, Harris, A, Koukourakis, M
Format:	Journal article
Language:	English
Published:	2002

Similar Items

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1alpha pathway and prognosis.
by: Giatromanolaki, A, et al.
Published: (2008)

Hypoxia inducible factors 1alpha and 2alpha are associated with VEGF expression and angiogenesis in gallbladder carcinomas.
by: Giatromanolaki, A, et al.
Published: (2006)

Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis.
by: Giatromanolaki, A, et al.
Published: (2003)

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin.
by: Giatromanolaki, A, et al.
Published: (2003)

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival.
by: Giatromanolaki, A, et al.
Published: (2001)

Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease.
by: Giatromanolaki, A, et al.
Published: (2003)

c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent.
by: Giatromanolaki, A, et al.
Published: (2004)

Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas.
by: Sivridis, E, et al.
Published: (2002)

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis.
by: Koukourakis, M, et al.
Published: (2003)

Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression.
by: Giatromanolaki, A, et al.
Published: (2006)

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.
by: Giatromanolaki, A, et al.
Published: (2003)

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia.
by: Koukourakis, M, et al.
Published: (2010)

BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer.
by: Giatromanolaki, A, et al.
Published: (2004)

C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer.
by: Koukourakis, M, et al.
Published: (2006)

Differential assessment of angiogenic activity and of vascular survival ability (VSA) in breast cancer.
by: Giatromanolaki, A, et al.
Published: (2002)

Autophagy and hypoxia in colonic adenomas related to aggressive features.
by: Giatromanolaki, A, et al.
Published: (2013)

Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer.
by: Koukourakis, M, et al.
Published: (2004)

Phosphorylated VEGFR2/KDR receptors are widely expressed in B-cell non-Hodgkin's lymphomas and correlate with hypoxia inducible factor activation.
by: Giatromanolaki, A, et al.
Published: (2008)

Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.
by: Koukourakis, M, et al.
Published: (2003)

Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group.
by: Koukourakis, M, et al.
Published: (2006)

LYVE-1 immunohistochemical assessment of lymphangiogenesis in endometrial and lung cancer.
by: Koukourakis, M, et al.
Published: (2005)

Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis.
by: Rasheed, S, et al.
Published: (2009)

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer.
by: Koukourakis, M, et al.
Published: (2002)

The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer.
by: Giatromanolaki, A, et al.
Published: (2008)

Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer.
by: Koukourakis, M, et al.
Published: (2006)

LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas.
by: Sivridis, E, et al.
Published: (2010)

Lactate dehydrogenase 5 expression in non-Hodgkin B-cell lymphomas is associated with hypoxia regulated proteins.
by: Giatromanolaki, A, et al.
Published: (2008)

Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
by: Hui, E, et al.
Published: (2002)

Inclusion of vasculature-related variables in the Dukes staging system of colon cancer.
by: Koukourakis, M, et al.
Published: (2005)

High DLL4 expression in tumour-associated vessels predicts for favorable radiotherapy outcome in locally advanced squamous cell head-neck cancer (HNSCC).
by: Koukourakis, M, et al.
Published: (2013)

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.
by: Koukourakis, M, et al.
Published: (2005)

Expression of phosphorylated (activated) receptors of vascular endothelial growth factor (VEGFR2/KDR) in colorectal cancer
by: Giatromanolaki, A, et al.
Published: (2007)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
by: Talks, K, et al.
Published: (2000)

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.
by: Leek, R, et al.
Published: (2002)

Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas.
by: Giatromanolaki, A, et al.
Published: (2010)

Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesis.
by: Sivridis, E, et al.
Published: (2002)

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
by: Wiesener, MS, et al.
Published: (1998)

Activated VEGFR2/KDR pathway in tumour cells and tumour associated vessels of colorectal cancer.
by: Giatromanolaki, A, et al.
Published: (2007)

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.
by: Wigfield, S, et al.
Published: (2008)

Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy
by: Koukourakis, MI, et al.
Published: (2009)