β2-Syntrophin Is a Cdk5 Substrate That Restrains the Motility of Insulin Secretory Granules

β2-Syntrophin Is a Cdk5 Substrate That Restrains the Motility of Insulin Secretory Granules

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The molecular basis for the interaction of insulin granules with the cortical cytoskeleton of pancreatic β-cells remains unknown. We have proposed that binding of the granule protein ICA512 to the PDZ domain of β2-syntrophin anchors granules to actin filaments and that the phosphorylation/dephosphor...

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Bibliographic Details
Main Authors:	Schubert, S, Knoch, K, Ouwendijk, J, Mohammed, S, Bodrov, Y, Jäger, M, Altkrüger, A, Wegbrod, C, Adams, M, Kim, Y, Froehner, S, Jensen, O, Kalaidzidis, Y, Solimena, M
Format:	Journal article
Language:	English
Published:	Public Library of Science 2010

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