Reprogramming the immune system using antibodies.
Tolerance induction induced by monoclonal antibodies or co-receptor blockade is robust enough to resist breakdown by adoptive transfer of lymphocytes. Such resistance, the hallmark of dominant tolerance, is mediated by CD4+ regulatory T cells. CD4+CD25+ T cells inhibit lymphopenia-mediated accumulat...
Main Authors: | Graca, L, Waldmann, H |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2006
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