A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical and SN samples. We show that the common genetic risk for Parkinson’s disease (PD) is associated with dopaminergic neuron (DaN)-specific gene...

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Bibliographic Details
Main Authors:	Agarwal, D, Sandor, C, Volpato, V, Caffrey, TM, Monzón-Sandoval, J, Bowden, R, Alegre-Abarrategui, J, Wade-Martins, R, Webber, C
Format:	Journal article
Language:	English
Published:	Nature Research 2020

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