Advancing specificity in delirium: the delirium subtyping initiative
<p><strong>Background</strong></p> Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiolo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2023
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| _version_ | 1824459143266697216 |
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| author | Bowman, EML Brummel, NE Caplan, GA Cunningham, C Evered, LA Fiest, KM Girard, TD Jackson, TA LaHue, SC Lindroth, HL Maclullich, AMJ McAuley, DF Oh, ES Oldham, MA Page, VJ Pandharipande, PP Potter, KM Sinha, P Slooter, AJC Sweeney, AM Tieges, Z Van Dellen, E Wilcox, ME Zetterberg, H Cunningham, EL |
| author_facet | Bowman, EML Brummel, NE Caplan, GA Cunningham, C Evered, LA Fiest, KM Girard, TD Jackson, TA LaHue, SC Lindroth, HL Maclullich, AMJ McAuley, DF Oh, ES Oldham, MA Page, VJ Pandharipande, PP Potter, KM Sinha, P Slooter, AJC Sweeney, AM Tieges, Z Van Dellen, E Wilcox, ME Zetterberg, H Cunningham, EL |
| author_sort | Bowman, EML |
| collection | OXFORD |
| description | <p><strong>Background</strong></p>
Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology.
<p><strong>Methods</strong></p>
The delirium subtyping initiative (DSI) held three sessions with an international panel of 25 experts.
<p><strong>Results</strong></p>
Meeting participants suggest further characterization of delirium features to complement the existing diagnostic and statistical manual of mental disorders fifth edition text revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations.
<p><strong>Discussion</strong></p>
The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes.
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| first_indexed | 2025-02-19T04:37:06Z |
| format | Journal article |
| id | oxford-uuid:e5b7b3ca-6a6e-41de-82ea-e642e8e96aa0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:37:06Z |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:e5b7b3ca-6a6e-41de-82ea-e642e8e96aa02025-01-31T19:09:19ZAdvancing specificity in delirium: the delirium subtyping initiativeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e5b7b3ca-6a6e-41de-82ea-e642e8e96aa0EnglishSymplectic ElementsWiley2023Bowman, EMLBrummel, NECaplan, GACunningham, CEvered, LAFiest, KMGirard, TDJackson, TALaHue, SCLindroth, HLMaclullich, AMJMcAuley, DFOh, ESOldham, MAPage, VJPandharipande, PPPotter, KMSinha, PSlooter, AJCSweeney, AMTieges, ZVan Dellen, EWilcox, MEZetterberg, HCunningham, EL<p><strong>Background</strong></p> Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. <p><strong>Methods</strong></p> The delirium subtyping initiative (DSI) held three sessions with an international panel of 25 experts. <p><strong>Results</strong></p> Meeting participants suggest further characterization of delirium features to complement the existing diagnostic and statistical manual of mental disorders fifth edition text revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. <p><strong>Discussion</strong></p> The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. |
| spellingShingle | Bowman, EML Brummel, NE Caplan, GA Cunningham, C Evered, LA Fiest, KM Girard, TD Jackson, TA LaHue, SC Lindroth, HL Maclullich, AMJ McAuley, DF Oh, ES Oldham, MA Page, VJ Pandharipande, PP Potter, KM Sinha, P Slooter, AJC Sweeney, AM Tieges, Z Van Dellen, E Wilcox, ME Zetterberg, H Cunningham, EL Advancing specificity in delirium: the delirium subtyping initiative |
| title | Advancing specificity in delirium: the delirium subtyping initiative |
| title_full | Advancing specificity in delirium: the delirium subtyping initiative |
| title_fullStr | Advancing specificity in delirium: the delirium subtyping initiative |
| title_full_unstemmed | Advancing specificity in delirium: the delirium subtyping initiative |
| title_short | Advancing specificity in delirium: the delirium subtyping initiative |
| title_sort | advancing specificity in delirium the delirium subtyping initiative |
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