Effects of ageing on the initial metabolic response to accidental injury
Background: little is known about the effects of ageing on the early metabolic response to injury. This response is thought to have evolved as a defence mechanism and may be particularly important in old people, who often present late to hospital after accidental injury. Setting: the accident and em...
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
1998
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| _version_ | 1826302043048902656 |
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| author | Barton, R Frayn, K Stoner, H Little, R |
| author_facet | Barton, R Frayn, K Stoner, H Little, R |
| author_sort | Barton, R |
| collection | OXFORD |
| description | Background: little is known about the effects of ageing on the early metabolic response to injury. This response is thought to have evolved as a defence mechanism and may be particularly important in old people, who often present late to hospital after accidental injury. Setting: the accident and emergency department of a teaching hospital. Subjects: 352 patients studied within 2 h of accidental injury, before the start of definitive treatment. Methods: a single blood sample was taken from each patient and the plasma concentrations of glucose, insulin, lactate, non-esterified fatty acids and cortisol were measured. Factorial analysis of variance was used to distinguish the effects of age (17-40, 41-65 and 66-92 years) from those of Injury Severity Score (1-6, 8-12, 13-24 and 25-66). Results: elderly patients had a higher concentration of glucose than young ones. There were no consistent age-effects for the other analytes. Although men were over-represented among the young and women among the elderly, a similar analysis by sex in the 41-65-year-old group suggested that this uneven distribution did not bias the results. Conclusion: elderly people do not have a defective early biochemical response to injury. |
| first_indexed | 2024-03-07T05:41:31Z |
| format | Journal article |
| id | oxford-uuid:e5b9871a-0121-46a1-a2a1-ca2a2868e3e6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:41:31Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:e5b9871a-0121-46a1-a2a1-ca2a2868e3e62022-03-27T10:26:07ZEffects of ageing on the initial metabolic response to accidental injuryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e5b9871a-0121-46a1-a2a1-ca2a2868e3e6EnglishSymplectic Elements at Oxford1998Barton, RFrayn, KStoner, HLittle, RBackground: little is known about the effects of ageing on the early metabolic response to injury. This response is thought to have evolved as a defence mechanism and may be particularly important in old people, who often present late to hospital after accidental injury. Setting: the accident and emergency department of a teaching hospital. Subjects: 352 patients studied within 2 h of accidental injury, before the start of definitive treatment. Methods: a single blood sample was taken from each patient and the plasma concentrations of glucose, insulin, lactate, non-esterified fatty acids and cortisol were measured. Factorial analysis of variance was used to distinguish the effects of age (17-40, 41-65 and 66-92 years) from those of Injury Severity Score (1-6, 8-12, 13-24 and 25-66). Results: elderly patients had a higher concentration of glucose than young ones. There were no consistent age-effects for the other analytes. Although men were over-represented among the young and women among the elderly, a similar analysis by sex in the 41-65-year-old group suggested that this uneven distribution did not bias the results. Conclusion: elderly people do not have a defective early biochemical response to injury. |
| spellingShingle | Barton, R Frayn, K Stoner, H Little, R Effects of ageing on the initial metabolic response to accidental injury |
| title | Effects of ageing on the initial metabolic response to accidental injury |
| title_full | Effects of ageing on the initial metabolic response to accidental injury |
| title_fullStr | Effects of ageing on the initial metabolic response to accidental injury |
| title_full_unstemmed | Effects of ageing on the initial metabolic response to accidental injury |
| title_short | Effects of ageing on the initial metabolic response to accidental injury |
| title_sort | effects of ageing on the initial metabolic response to accidental injury |
| work_keys_str_mv | AT bartonr effectsofageingontheinitialmetabolicresponsetoaccidentalinjury AT fraynk effectsofageingontheinitialmetabolicresponsetoaccidentalinjury AT stonerh effectsofageingontheinitialmetabolicresponsetoaccidentalinjury AT littler effectsofageingontheinitialmetabolicresponsetoaccidentalinjury |