Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder.
BACKGROUND: Recent evidence has suggested that the short allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin gene [SLC6A4]) is associated with increased risk of depressive disorder but only among individuals exposed to social adversity. We repo...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797100722137858048 |
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| author | Surtees, P Wainwright, N Willis-Owen, SA Luben, R Day, N Flint, J |
| author_facet | Surtees, P Wainwright, N Willis-Owen, SA Luben, R Day, N Flint, J |
| author_sort | Surtees, P |
| collection | OXFORD |
| description | BACKGROUND: Recent evidence has suggested that the short allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin gene [SLC6A4]) is associated with increased risk of depressive disorder but only among individuals exposed to social adversity. We report an investigation designed to replicate this finding. METHODS: Data were available from a non-clinical sample of 4,175 adult men and women, ages 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom) study. Evidence of past-year prevalent episodic major depressive disorder (MDD), defined by restricted DSM-IV diagnostic criteria, was assessed through questionnaire. Adverse experiences in childhood and in adulthood (during the five years preceding assessment) were also assessed through self-report. The 5-HTTLPR variant was genotyped according to published protocols. RESULTS: One-year prevalent MDD criteria were met by 298 study participants. The experience of social adversity (both in childhood and adulthood) was strongly associated with increased rates of past-year prevalent MDD. No gene by environment (GxE) interactions between the 5-HTTLPR genotype, social adversity, and MDD were observed. CONCLUSIONS: This study has not replicated a previous finding of a GxE interaction between the 5-HTTLPR genotype, social adversity, and depression. |
| first_indexed | 2024-03-07T05:41:39Z |
| format | Journal article |
| id | oxford-uuid:e5c7fd7e-6d84-41d3-9eb1-dcf3e6513722 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:41:39Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:e5c7fd7e-6d84-41d3-9eb1-dcf3e65137222022-03-27T10:26:24ZSocial adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e5c7fd7e-6d84-41d3-9eb1-dcf3e6513722EnglishSymplectic Elements at Oxford2006Surtees, PWainwright, NWillis-Owen, SALuben, RDay, NFlint, JBACKGROUND: Recent evidence has suggested that the short allele of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin gene [SLC6A4]) is associated with increased risk of depressive disorder but only among individuals exposed to social adversity. We report an investigation designed to replicate this finding. METHODS: Data were available from a non-clinical sample of 4,175 adult men and women, ages 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom) study. Evidence of past-year prevalent episodic major depressive disorder (MDD), defined by restricted DSM-IV diagnostic criteria, was assessed through questionnaire. Adverse experiences in childhood and in adulthood (during the five years preceding assessment) were also assessed through self-report. The 5-HTTLPR variant was genotyped according to published protocols. RESULTS: One-year prevalent MDD criteria were met by 298 study participants. The experience of social adversity (both in childhood and adulthood) was strongly associated with increased rates of past-year prevalent MDD. No gene by environment (GxE) interactions between the 5-HTTLPR genotype, social adversity, and MDD were observed. CONCLUSIONS: This study has not replicated a previous finding of a GxE interaction between the 5-HTTLPR genotype, social adversity, and depression. |
| spellingShingle | Surtees, P Wainwright, N Willis-Owen, SA Luben, R Day, N Flint, J Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title | Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title_full | Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title_fullStr | Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title_full_unstemmed | Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title_short | Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. |
| title_sort | social adversity the serotonin transporter 5 httlpr polymorphism and major depressive disorder |
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