Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention

Genomic risk prediction of coronary artery disease in 480,000 adults: implications for primary prevention

<strong>Background</strong> Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Inouye, M, Abraham, G, Nelson, C, Wood, A, Sweeting, M, Dudbridge, F, Lai, F, Kaptoge, S, Brozynska, M, Wang, T, Ye, S, Webb, T, Rutter, M, Tzoulaki, I, Patel, R, Loos, R, Keavney, B, Hemingway, H, Thompson, J, Watkins, H, Deloukas, P, Di Angelantonio, E, Butterworth, A, Danesh, J, Samani, N, UK Biobank CardioMetabolic Consortium CHD Working Group
Format: Journal article
Sprache:English
Veröffentlicht: Elsevier 2018

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