Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.

Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and con...

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Príomhchruthaitheoirí: Fullerton, J, Cubin, M, Tiwari, H, Wang, C, Bomhra, A, Davidson, S, Miller, S, Fairburn, C, Goodwin, G, Neale, M, Fiddy, S, Mott, R, Allison, D, Flint, J
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2003
_version_ 1826302075969994752
author Fullerton, J
Cubin, M
Tiwari, H
Wang, C
Bomhra, A
Davidson, S
Miller, S
Fairburn, C
Goodwin, G
Neale, M
Fiddy, S
Mott, R
Allison, D
Flint, J
author_facet Fullerton, J
Cubin, M
Tiwari, H
Wang, C
Bomhra, A
Davidson, S
Miller, S
Fairburn, C
Goodwin, G
Neale, M
Fiddy, S
Mott, R
Allison, D
Flint, J
author_sort Fullerton, J
collection OXFORD
description Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and concordant sibling pairs, selected from 34,580 sibling pairs in the southwest of England who completed a personality questionnaire. We performed a genomewide scan for quantitative-trait loci (QTLs) that influence variation in the personality trait of neuroticism, or emotional stability, and we established genomewide empirical significance thresholds by simulation. The maximum pointwise P values, expressed as the negative logarithm (base 10), were found on 1q (3.95), 4q (3.84), 7p (3.90), 12q (4.74), and 13q (3.81). These five loci met or exceeded the 5% genomewide significance threshold of 3.8 (negative logarithm of the P value). QTLs on chromosomes 1, 12, and 13 are likely to be female specific. One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous.
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spelling oxford-uuid:e5e618b1-e3d2-4bdb-8ac6-b86b17752dd02022-03-27T10:27:19ZLinkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e5e618b1-e3d2-4bdb-8ac6-b86b17752dd0EnglishSymplectic Elements at Oxford2003Fullerton, JCubin, MTiwari, HWang, CBomhra, ADavidson, SMiller, SFairburn, CGoodwin, GNeale, MFiddy, SMott, RAllison, DFlint, JSeveral theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and concordant sibling pairs, selected from 34,580 sibling pairs in the southwest of England who completed a personality questionnaire. We performed a genomewide scan for quantitative-trait loci (QTLs) that influence variation in the personality trait of neuroticism, or emotional stability, and we established genomewide empirical significance thresholds by simulation. The maximum pointwise P values, expressed as the negative logarithm (base 10), were found on 1q (3.95), 4q (3.84), 7p (3.90), 12q (4.74), and 13q (3.81). These five loci met or exceeded the 5% genomewide significance threshold of 3.8 (negative logarithm of the P value). QTLs on chromosomes 1, 12, and 13 are likely to be female specific. One locus, on chromosome 1, is syntenic with that reported from QTL mapping of rodent emotionality, an animal model of neuroticism, suggesting that some animal and human QTLs influencing emotional stability may be homologous.
spellingShingle Fullerton, J
Cubin, M
Tiwari, H
Wang, C
Bomhra, A
Davidson, S
Miller, S
Fairburn, C
Goodwin, G
Neale, M
Fiddy, S
Mott, R
Allison, D
Flint, J
Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title_full Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title_fullStr Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title_full_unstemmed Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title_short Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism.
title_sort linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative trait loci that influence variation in the human personality trait neuroticism
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