RNA-binding activity of Trim25 is mediated by its PRY/SPRY domain and is required for ubiquitination

<p><strong>Background</strong> TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology...

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Autori principali: Choudhury, N, Heikel, G, Trubitsyna, M, Kubik, P, Nowak, J, Webb, S, Granneman, S, Spanos, C, Rappsilber, J, Castello, A, Michlewski, G
Natura: Journal article
Pubblicazione: BioMed Central 2017