Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth

Abnormal uteroplacental remodeling leads to placental hypoperfusion, causing fetal growth restriction and pregnancy-related hypertension, which are associated with endothelial dysfunction and markers of reduced vascular NO bioavailability and oxidative stress. Tetrahydrobiopterin (BH4) is a redox co...

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Bibliographic Details
Main Authors:	Chuaiphichai, S, Yu, G, Tan, C, Whiteman, C, Douglas, G, Dickinson, Y, Drydale, E, Appari, M, Zhang, W, Crabtree, M, McNeill, E, Hale, A, Lewandowski, A, Alp, N, Vatish, M, Leeson, P, Channon, K
Format:	Journal article
Language:	English
Published:	American Heart Association 2021

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