Signalling hypoxia by HIF hydroxylases.
Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, be...
| Main Authors: | , |
|---|---|
| 格式: | Journal article |
| 語言: | English |
| 出版: |
2005
|
| _version_ | 1826302135257530368 |
|---|---|
| author | Schofield, C Ratcliffe, P |
| author_facet | Schofield, C Ratcliffe, P |
| author_sort | Schofield, C |
| collection | OXFORD |
| description | Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, belong to the superfamily of non-haem Fe(II)-dependent oxygenases that use the citric acid cycle intermediate 2-oxoglutarate (2OG) as a co-substrate. We review biochemical and physiological data that demonstrate a central role for these oxygenases in integrating multiple signals that coordinate cellular responses to hypoxia. |
| first_indexed | 2024-03-07T05:42:56Z |
| format | Journal article |
| id | oxford-uuid:e6353def-8d0c-486b-a747-3572c3fca7a9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:42:56Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:e6353def-8d0c-486b-a747-3572c3fca7a92022-03-27T10:29:32ZSignalling hypoxia by HIF hydroxylases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e6353def-8d0c-486b-a747-3572c3fca7a9EnglishSymplectic Elements at Oxford2005Schofield, CRatcliffe, PAnalysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, belong to the superfamily of non-haem Fe(II)-dependent oxygenases that use the citric acid cycle intermediate 2-oxoglutarate (2OG) as a co-substrate. We review biochemical and physiological data that demonstrate a central role for these oxygenases in integrating multiple signals that coordinate cellular responses to hypoxia. |
| spellingShingle | Schofield, C Ratcliffe, P Signalling hypoxia by HIF hydroxylases. |
| title | Signalling hypoxia by HIF hydroxylases. |
| title_full | Signalling hypoxia by HIF hydroxylases. |
| title_fullStr | Signalling hypoxia by HIF hydroxylases. |
| title_full_unstemmed | Signalling hypoxia by HIF hydroxylases. |
| title_short | Signalling hypoxia by HIF hydroxylases. |
| title_sort | signalling hypoxia by hif hydroxylases |
| work_keys_str_mv | AT schofieldc signallinghypoxiabyhifhydroxylases AT ratcliffep signallinghypoxiabyhifhydroxylases |