Signalling hypoxia by HIF hydroxylases.

Signalling hypoxia by HIF hydroxylases.

Analysis of oxygen sensitive pathways that regulate the hypoxia inducible factor (HIF) transcriptional system has revealed a novel role for oxygenases in signalling hypoxia. The enzymes, which catalyse hydroxylation of specific prolyl and asparaginyl residues in the regulatory HIF-alpha subunits, be...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Schofield, C, Ratcliffe, P
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2005

Antzeko izenburuak

Oxygen sensing by HIF hydroxylases.
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Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
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Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
nork: Webb, J, et al.
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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
nork: Hewitson, K, et al.
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The HIF hydroxylase pathway and the tumour microenvironment
nork: Ratcliffe, P
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Regulation of HIF: prolyl hydroxylases.
nork: Stolze, I, et al.
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Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
nork: Chowdhury, R, et al.
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From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
nork: Ratcliffe, P
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Pharmacological targeting of the HIF hydroxylases - A new field in medicine development.
nork: Chan, M, et al.
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2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
nork: Mole, D, et al.
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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
nork: Cockman, M, et al.
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The use of dioxygen by HIF prolyl hydroxylase (PHD1).
nork: McNeill, L, et al.
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Therapeutic manipulation of the HIF hydroxylases.
nork: Nagel, S, et al.
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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
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Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
nork: Hewitson, K, et al.
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Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases
nork: Chan, M
Argitaratua: (2014)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
nork: Schlemminger, I, et al.
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
nork: Cockman, M, et al.
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nork: Yeoh, KK
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Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?
nork: Moritz J. Strowitzki, et al.
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nork: Kaelin, W, et al.
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HIF-1 and HIF-2: working alone or together in hypoxia?
nork: Ratcliffe, P
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Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
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Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases.
nork: Lienard, B, et al.
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Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
nork: Tian, Y, et al.
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Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
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Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
nork: Chowdhury, R, et al.
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Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
nork: Matthew E Cockman, et al.
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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
nork: Masson, N, et al.
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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
nork: Masson, N, et al.
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Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
nork: Stolze, I, et al.
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Biochemistry of the hypoxia-inducible factor hydroxylases
nork: Fiorini, G, et al.
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Studies on HIF hydroxylases
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Regulation of angiogenesis by hypoxia: role of the HIF system.
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HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
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Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
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