Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies
Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai co...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2021
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| _version_ | 1826302136813617152 |
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| author | Sriboonvorakul, N Pan-Ngum, W Poovorawan, K Muangnoicharoen, S Quinn, LM Tan, BK |
| author_facet | Sriboonvorakul, N Pan-Ngum, W Poovorawan, K Muangnoicharoen, S Quinn, LM Tan, BK |
| author_sort | Sriboonvorakul, N |
| collection | OXFORD |
| description | Type 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (n = 65 single-drug-treated; n = 38 multi-drug-treated) compared to healthy controls (n = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (p = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (p = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population. |
| first_indexed | 2024-03-07T05:42:58Z |
| format | Journal article |
| id | oxford-uuid:e637e0cc-62b9-4f5c-80f3-450ae0c5cb6f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:42:58Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:e637e0cc-62b9-4f5c-80f3-450ae0c5cb6f2022-03-27T10:29:35ZLow branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e637e0cc-62b9-4f5c-80f3-450ae0c5cb6fEnglishSymplectic ElementsMDPI2021Sriboonvorakul, NPan-Ngum, WPoovorawan, KMuangnoicharoen, SQuinn, LMTan, BKType 2 diabetes mellitus (T2DM) is a growing public health challenge for Thailand (current prevalence ~10.0%). Amino acids offer novel biomarkers to predict risk of T2DM and indicate sub-optimal disease management, which could facilitate earlier treatment. We studied amino acid profiles in a Thai cohort comprising of individuals with T2DM (n = 65 single-drug-treated; n = 38 multi-drug-treated) compared to healthy controls (n = 104) using liquid chromatography-mass spectrometry. Age and BMI were significantly lower in the healthy controls compared to the single or multi-treated T2DM groups. The BCAA (leucine and valine) were significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p < 0.001) and isoleucine was significantly lower in the single-treated compared to the healthy controls (p = 0.014). These findings beg the question whether BCAAs supplementation be beneficial in T2DM patients treated with single or multi-drug therapy? Tyrosine was significantly lower in the single and multi-treated T2DM groups compared to healthy controls (p < 0.001 and p = 0.002), whereas phenylalanine was significantly higher in the multi-treated T2DM group compared to the single treated T2DM group (p = 0.045). We provide novel insights into the effects of diabetes treatments on these amino acids in insulin resistant states such as T2DM in a unique but understudied Thai population. |
| spellingShingle | Sriboonvorakul, N Pan-Ngum, W Poovorawan, K Muangnoicharoen, S Quinn, LM Tan, BK Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title | Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title_full | Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title_fullStr | Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title_full_unstemmed | Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title_short | Low branched chain amino acids and tyrosine in Thai patients with type 2 diabetes mellitus treated with metformin and metformin-sulfonylurea combination therapies |
| title_sort | low branched chain amino acids and tyrosine in thai patients with type 2 diabetes mellitus treated with metformin and metformin sulfonylurea combination therapies |
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