Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

Patients with Peutz-Jeghers' syndrome (PJS) develop hamartomatous gastrointestinal polyps and characteristic pigmentation, as a result of germline mutations in the LKB1 gene. The hamartomas in PJS were long considered to be without malignant potential. There is, however, accumulating epidemiolo...

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Detalhes bibliográficos
Main Authors: Wang, Z, Ellis, I, Zauber, P, Iwama, T, Marchese, C, Talbot, I, Xue, W, Yan, Z, Tomlinson, I
Formato: Journal article
Idioma:English
Publicado em: 1999

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