The genetics of Graves' disease.
Graves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributi...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1826302153265774592 |
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| author | Gough, S |
| author_facet | Gough, S |
| author_sort | Gough, S |
| collection | OXFORD |
| description | Graves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributions seems to vary between data sets and geographic populations. Genome-wide searches are beginning to identify new loci, including GD-1, GD-2, and GD-3, although these loci have only been found in one data set. Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes. |
| first_indexed | 2024-03-07T05:43:14Z |
| format | Journal article |
| id | oxford-uuid:e64ca805-62f4-4215-81e4-b170fa3666d2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:43:14Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:e64ca805-62f4-4215-81e4-b170fa3666d22022-03-27T10:30:10ZThe genetics of Graves' disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e64ca805-62f4-4215-81e4-b170fa3666d2EnglishSymplectic Elements at Oxford2000Gough, SGraves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributions seems to vary between data sets and geographic populations. Genome-wide searches are beginning to identify new loci, including GD-1, GD-2, and GD-3, although these loci have only been found in one data set. Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes. |
| spellingShingle | Gough, S The genetics of Graves' disease. |
| title | The genetics of Graves' disease. |
| title_full | The genetics of Graves' disease. |
| title_fullStr | The genetics of Graves' disease. |
| title_full_unstemmed | The genetics of Graves' disease. |
| title_short | The genetics of Graves' disease. |
| title_sort | genetics of graves disease |
| work_keys_str_mv | AT goughs thegeneticsofgravesdisease AT goughs geneticsofgravesdisease |