Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
Factor-inhibiting hypoxia-inducible factor (FIH) is an Fe(II)/2-oxoglutarate-dependent dioxygenase that acts as a negative regulator of the hypoxia-inducible factor (HIF) by catalysing β-hydroxylation of an asparaginyl residue in its C-terminal transcriptional activation domain (CAD). In addition to...
Autori principali: | Yang, M, Chowdhury, R, Ge, W, Hamed, R, McDonough, M, Claridge, T, Kessler, B, Cockman, M, Ratcliffe, P, Schofield, C |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
2011
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