Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

Factor-inhibiting hypoxia-inducible factor (FIH) is an Fe(II)/2-oxoglutarate-dependent dioxygenase that acts as a negative regulator of the hypoxia-inducible factor (HIF) by catalysing β-hydroxylation of an asparaginyl residue in its C-terminal transcriptional activation domain (CAD). In addition to...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Yang, M, Chowdhury, R, Ge, W, Hamed, R, McDonough, M, Claridge, T, Kessler, B, Cockman, M, Ratcliffe, P, Schofield, C
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2011

Παρόμοια τεκμήρια

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
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Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
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Έκδοση: (2009)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
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Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains
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Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins
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FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
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Έκδοση: (2016-01-01)

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Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.
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Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
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Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
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