Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

Factor-inhibiting hypoxia-inducible factor (FIH) is an Fe(II)/2-oxoglutarate-dependent dioxygenase that acts as a negative regulator of the hypoxia-inducible factor (HIF) by catalysing β-hydroxylation of an asparaginyl residue in its C-terminal transcriptional activation domain (CAD). In addition to...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Yang, M, Chowdhury, R, Ge, W, Hamed, R, McDonough, M, Claridge, T, Kessler, B, Cockman, M, Ratcliffe, P, Schofield, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2011

Antzeko izenburuak

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
nork: Cockman, M, et al.
Argitaratua: (2009)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
nork: Cockman, M, et al.
Argitaratua: (2006)

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
nork: Cockman, M, et al.
Argitaratua: (2009)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
nork: Yang, M, et al.
Argitaratua: (2011)

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
nork: Coleman, M, et al.
Argitaratua: (2007)

Biochemical and structural insights into FIH-catalysed hydroxylation of transient receptor potential ankyrin repeat domains
nork: Saward, B, et al.
Argitaratua: (2022)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
nork: McNeill, L, et al.
Argitaratua: (2002)

Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins
nork: Leissing, TM, et al.
Argitaratua: (2022)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
nork: Lancaster, D, et al.
Argitaratua: (2004)

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.
nork: Kelly, L, et al.
Argitaratua: (2009)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
nork: Lancaster, D, et al.
Argitaratua: (2004)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
nork: Banerji, B, et al.
Argitaratua: (2005)

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation
nork: Singleton, R, et al.
Argitaratua: (2011)

Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.
nork: Singleton, R, et al.
Argitaratua: (2011)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
nork: Hewitson, K, et al.
Argitaratua: (2008)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
nork: Tian, Y, et al.
Argitaratua: (2011)

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
nork: Hewitson, K, et al.
Argitaratua: (2002)

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.
nork: Loenarz, C, et al.
Argitaratua: (2014)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
nork: Stolze, I, et al.
Argitaratua: (2004)

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
nork: Yang, M, et al.
Argitaratua: (2013)

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
nork: Webb, J, et al.
Argitaratua: (2009)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
nork: Abboud, M, et al.
Argitaratua: (2018)

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
nork: Carsten C Scholz, et al.
Argitaratua: (2016-01-01)

Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
nork: Mantri, M, et al.
Argitaratua: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
nork: Masson, N, et al.
Argitaratua: (2012)

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
nork: Masson, N, et al.
Argitaratua: (2012)

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.
nork: Hardy, A, et al.
Argitaratua: (2009)

Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism
nork: Holliday, J, et al.
Argitaratua: (2018)

Signalling cross talk of the HIF system: involvement of the FIH protein.
nork: Coleman, M, et al.
Argitaratua: (2009)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
nork: Pollard, P, et al.
Argitaratua: (2008)

Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively
nork: Wang, Y, et al.
Argitaratua: (2018)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
nork: Wu, Y, et al.
Argitaratua: (2021)

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.
nork: Hamed, R, et al.
Argitaratua: (2010)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
nork: Chowdhury, R, et al.
Argitaratua: (2009)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
nork: Chowdhury, R, et al.
Argitaratua: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
nork: Chowdhury, R, et al.
Argitaratua: (2011)

Selective inhibition of factor inhibiting hypoxia-inducible factor.
nork: McDonough, M, et al.
Argitaratua: (2005)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
nork: Conejo-Garcia, A, et al.
Argitaratua: (2010)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
nork: Conejo-Garcia, A, et al.
Argitaratua: (2005)

Investigating the role of factor inhibiting HIF (FIH) in tumourigenesis
nork: Ma, J
Argitaratua: (2017)