GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.

Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS). Acquired GATA1 mutations are present in both TAM and ML-DS. Current definitions of TAM specify neither the percentage of blasts nor the...

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Hlavní autoři: Roberts, I, Alford, K, Hall, G, Juban, G, Richmond, H, Norton, A, Vallance, G, Perkins, K, Marchi, E, McGowan, S, Roy, A, Cowan, G, Anthony, M, Gupta, A, Ho, J, Uthaya, S, Curley, A, Rasiah, S, Watts, T, Nicholl, R, Bedford-Russell, A, Blumberg, R, Thomas, A, Gibson, B, Halsey, C, Lee, P, Godambe, S, Sweeney, C, Bhatnagar, N, Goriely, A, Campbell, P, Vyas, P
Médium: Journal article
Jazyk:English
Vydáno: American Society of Hematology 2013

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